Date published: 2026-2-11

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Unoprostone (CAS 120373-36-6)

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Alternate Names:
13,14-dihydro-15-keto-20-ethyl PGF2α
Application:
Unoprostone is a PGF analog
CAS Number:
120373-36-6
Purity:
>98%
Molecular Weight:
382.5
Molecular Formula:
C22H38O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Unoprostone is a synthetic molecule that engages with biological systems by acting on prostaglandin receptors. This interaction is pivotal for its role in research focused on elucidating cellular signaling pathways. Specifically, unoprostone′s mechanism involves the activation of these receptors, leading to a cascade of intracellular events that modulate the outflow of aqueous humor through the uveoscleral pathway. This particular pathway is necessary for maintaining intraocular pressure within optimal ranges, a key aspect in ocular physiology studies. By facilitating an increased outflow of aqueous humor, unoprostone helps researchers understand the molecular dynamics that regulate ocular pressure, offering a model to explore how changes at the receptor level can influence overall eye health. The effects of unoprostone at the molecular level provide insights into the regulation of fluid dynamics in cellular environments, making it useful in the study of prostaglandin receptor pharmacology and their broader biological implications.


Unoprostone (CAS 120373-36-6) References

  1. A preliminary risk-benefit assessment of latanoprost and unoprostone in open-angle glaucoma and ocular hypertension.  |  Eisenberg, DL. and Camras, CB. 1999. Drug Saf. 20: 505-14. PMID: 10392667
  2. Effects of topical unoprostone and latanoprost on acute and recurrent herpetic keratitis in the rabbit.  |  Kaufman, HE., et al. 2001. Am J Ophthalmol. 131: 643-6. PMID: 11336941
  3. Mechanisms of action of unoprostone on trabecular meshwork contractility.  |  Thieme, H., et al. 2001. Invest Ophthalmol Vis Sci. 42: 3193-201. PMID: 11726622
  4. Safety of unoprostone isopropyl as mono- or adjunctive therapy in patients with primary open-angle glaucoma or ocular hypertension.  |  de Arruda Mello, PA., et al. 2002. Drug Saf. 25: 583-97. PMID: 12113643
  5. Neuroprotective properties of a synthetic docosanoid, unoprostone isopropyl: clinical benefits in the treatment of glaucoma.  |  Melamed, S. 2002. Drugs Exp Clin Res. 28: 63-73. PMID: 12224379
  6. Unoprostone isopropyl ester darkens iris color in pigmented rabbits with sympathetic denervation.  |  Zhan, GL., et al. 2003. J Glaucoma. 12: 383-9. PMID: 12897587
  7. Cellular and molecular effects of unoprostone as a BK channel activator.  |  Cuppoletti, J., et al. 2007. Biochim Biophys Acta. 1768: 1083-92. PMID: 17307133
  8. Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels.  |  Tsuruma, K., et al. 2011. Mol Vis. 17: 3556-65. PMID: 22219651
  9. Unoprostone isopropyl and metabolite M1 activate BK channels and prevent ET-1-induced [Ca²⁺]i increases in human trabecular meshwork and smooth muscle.  |  Cuppoletti, J., et al. 2012. Invest Ophthalmol Vis Sci. 53: 5178-89. PMID: 22786902
  10. Current status of unoprostone for the management of glaucoma and the future of its use in the treatment of retinal disease.  |  Harms, NV. and Toris, CB. 2013. Expert Opin Pharmacother. 14: 105-13. PMID: 23199345
  11. Regeneration of optic nerve fibers with unoprostone, a prostaglandin-related antiglaucoma drug, in adult cats.  |  Sagawa, H., et al. 2014. Jpn J Ophthalmol. 58: 100-9. PMID: 24129676
  12. An evidence-based review of unoprostone isopropyl ophthalmic solution 0.15% for glaucoma: place in therapy.  |  Fung, DS. and Whitson, JT. 2014. Clin Ophthalmol. 8: 543-54. PMID: 24648719
  13. Unoprostone activation of BK (KCa1.1) channel splice variants.  |  Yu, L., et al. 2015. Biochim Biophys Acta. 1848: 2859-67. PMID: 26277265

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Unoprostone, 1 mg

sc-205536
1 mg
$73.00

Unoprostone, 10 mg

sc-205536A
10 mg
$587.00