UCH-L1 Antibody (31A3): sc-58595
- UCH-L1 Antibody (31A3) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against native UCH-L1 of human origin
- recommended for detection of UCH-L1 on neuronal cell bodies and axons in the CNS and periphery, small nerve fibers in peripheral tissues, neuroendocrine cells in the pituitary, thyroid, pancreas and tumors of the DNES of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including and bovine and porcine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for UCH-L1 Antibody (31A3) for WB and IHC(P) applications. These reagents are now offered in bundles with UCH-L1 Antibody (31A3) (see ordering information below).
UCH-L1 Antibody (31A3) is a mouse monoclonal IgG1 antibody that detects UCH-L1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. UCH-L1, or ubiquitin C-terminal hydrolase, plays a crucial role in the ubiquitin-proteasome pathway by hydrolyzing small C-terminal adducts of ubiquitin to release free ubiquitin monomers, which are essential for protein degradation and cellular regulation. UCH-L1 is predominantly expressed in neurons and cells of the diffuse neuroendocrine system, with significant localization in brain regions such as the substantia nigra, where UCH-L1 constitutes 1-2% of total soluble brain protein. UCH-L1′s presence in Lewy bodies highlights UCH-L1′s potential involvement in neurodegenerative diseases, particularly Parkinson′s disease, making UCH-L1 a valuable target for research. The gene encoding UCH-L1 is located on human chromosome 4p13, and UCH-L1′s structural similarity to UCH-L3, which is 54% identical and serves as a predominant thiol protease with high-affinity binding sites for ubiquitin, underscores UCH-L1′s importance in maintaining cellular homeostasis and implications in neurodegenerative disorders. Anti-UCH-L1 antibody (31A3) is an essential tool for researchers investigating the role of ubiquitin-related pathways in various biological processes and diseases.
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UCH-L1 Antibody (31A3) References:
- UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation. | Lohmann, F., et al. 2014. Biochim Biophys Acta. 1842: 945-58. PMID: 24583340
- UCH-L1 Inhibition Decreases the Microtubule-Binding Function of Tau Protein. | Xie, M., et al. 2016. J Alzheimers Dis. 49: 353-63. PMID: 26444754
- UCH-L1-containing exosomes mediate chemotherapeutic resistance transfer in breast cancer. | Ning, K., et al. 2017. J Surg Oncol. 115: 932-940. PMID: 28334432
- UCH-L1 Inhibition Suppresses tau Aggresome Formation during Proteasomal Impairment. | Yu, Q., et al. 2018. Mol Neurobiol. 55: 3812-3821. PMID: 28540657
- UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway. | Luo, Y., et al. 2018. J Cell Biochem. 119: 691-700. PMID: 28636190
- UCH-L1 inhibition aggravates mossy fiber sprouting in the pentylenetetrazole kindling model. | Wen, Y., et al. 2018. Biochem Biophys Res Commun. 503: 2312-2318. PMID: 29964011
- UCH-L1 is a Poor Serum Biomarker of Murine Traumatic Brain Injury After Polytrauma. | Morris, MC., et al. 2019. J Surg Res. 244: 63-68. PMID: 31279265
- Association of Ubiquitin C-Terminal Hydrolase-L1 (Uch-L1) serum levels with cognition and brain energy metabolism. | Zhang, M., et al. 2022. Eur Rev Med Pharmacol Sci. 26: 3656-3663. PMID: 35647847
- Associations of blood UCH-L1 and NfL levels with cognitive dysfunction in Parkinson's disease patients. | Dong, L., et al. 2023. Neurosci Lett. 804: 137219. PMID: 37023526
- Plasma ubiquitin C-terminal hydrolase-L1 (UCH-L1) level as a blood biomarker of neurological damage after allogeneic hematopoietic cell transplantation. | Okada, Y., et al. 2023. Int J Hematol. 118: 340-346. PMID: 37480445
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UCH-L1 Antibody (31A3) | sc-58595 | 200 µg/ml | $322.00 | |||
UCH-L1 Antibody (31A3): m-IgG Fc BP-HRP Bundle | sc-539087 | 200 µg Ab; 10 µg BP | $361.00 | |||
UCH-L1 Antibody (31A3): m-IgG1 BP-HRP Bundle | sc-541250 | 200 µg Ab; 20 µg BP | $361.00 |