UBE2E1 Antibody (42): sc-136113
- UBE2E1 Antibody (42) is a mouse monoclonal IgG1 UBE2E1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 46-58 of UBE2E1 of human origin
- UBE2E1 Antibody (42) is recommended for detection of UBE2E1 of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including canine
- m-IgGκ BP-HRP is the preferred secondary detection reagent for UBE2E1 Antibody (42) for WB applications. This reagent is now offered in a bundle with UBE2E1 Antibody (42) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
UBE2E1 Antibody (42) is a mouse monoclonal IgG1 antibody that detects UBE2E1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-UBE2E1 antibody (42) is available as the non-conjugated format. UBE2E1 plays a crucial role in the ubiquitin-proteasome system, which is essential for regulating protein degradation, cellular signaling, and maintaining protein homeostasis. Specifically, UBE2E1 functions as an E2 ubiquitin-conjugating enzyme, facilitating the transfer of ubiquitin to target proteins, thereby marking them for degradation or altering their activity. This process is vital for various cellular functions, including cell cycle regulation and response to stress, making UBE2E1 a significant player in maintaining cellular health and preventing diseases such as cancer. UBE2E1 interacts with several important proteins, including the tumor suppressor protein TSSC5, which underscores its role in critical cellular pathways. The ability of UBE2E1 to mediate the ubiquitination of specific substrates highlights its importance in cellular regulation and the potential implications in therapeutic strategies targeting the ubiquitin-proteasome pathway.
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UBE2E1 Antibody (42) References:
- Promoter analysis of the human ubiquitin-conjugating enzyme gene family UBE2L1-4, including UBE2L3 which encodes UbcH7. | Ardley, HC., et al. 2000. Biochim Biophys Acta. 1491: 57-64. PMID: 10760570
- Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. | Ardley, HC., et al. 2001. J Biol Chem. 276: 19640-7. PMID: 11278816
- Getting into position: the catalytic mechanisms of protein ubiquitylation. | Passmore, LA. and Barford, D. 2004. Biochem J. 379: 513-25. PMID: 14998368
- Orchestra for assembly and fate of polyubiquitin chains. | Kuhlbrodt, K., et al. 2005. Essays Biochem. 41: 1-14. PMID: 16250894
- Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105. | Yamada, HY. and Gorbsky, GJ. 2006. Oncogene. 25: 1330-9. PMID: 16314844
- Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. | Takeuchi, T., et al. 2005. J Biochem. 138: 711-9. PMID: 16428300
- Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5. | Nuber, U., et al. 1996. J Biol Chem. 271: 2795-800. PMID: 8576257
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UBE2E1 Antibody (42) | sc-136113 | 200 µg/ml | $322.00 | |||
UBE2E1 Antibody (42): m-IgGκ BP-HRP Bundle | sc-551076 | 200 µg Ab; 40 µg BP | $361.00 |