UBA3 Antibody (B-10): sc-377352
- UBA3 Antibody (B-10) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 317-463 mapping at the C-terminus of UBA3 of human origin
- recommended for detection of UBA3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for UBA3 Antibody (B-10) for WB applications. This reagent is now offered in a bundle with UBA3 Antibody (B-10) (see ordering information below).
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UBA3 Antibody (B-10) is a mouse monoclonal IgG2a light chain antibody that detects UBA3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). UBA3, also known as NEDD8-activating enzyme E1 catalytic subunit or UBE1C, is a 463 amino acid protein that plays a crucial role in the ubiquitin-like modification pathway, specifically in the activation of NEDD8, a protein that is vital for regulating various cellular processes including cell division, signaling, and embryogenesis. Anti-UBA3 antibody (B-10) facilitates the conjugation of NEDD8 to target proteins, which is essential for the proper functioning of the cullin-RING ligase complex, a key player in the ubiquitin-proteasome system. This process not only helps maintain cellular homeostasis by regulating protein degradation but also influences critical developmental pathways and responses to cellular stress. UBA3 is expressed in a variety of tissues and exists in two isoforms due to alternative splicing, highlighting its versatile role in cellular functions. UBA3 (B-10) antibody serves as an invaluable tool for researchers studying the dynamics of protein modification and its implications in health and disease.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
UBA3 Antibody (B-10) | sc-377352 | 200 µg/ml | $322.00 | |||
UBA3 Antibody (B-10): m-IgG Fc BP-HRP Bundle | sc-540710 | 200 µg Ab; 10 µg BP | $361.00 |