Date published: 2025-10-15

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U 99194 maleate (CAS 234757-41-6)

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Alternate Names:
2,3-Dihydro-5,6-dimethoxy-N, N-dipropyl-1H-inden-2-amine maleate
Application:
U 99194 maleate is potent and selective D3DR antagonist
CAS Number:
234757-41-6
Purity:
≥98%
Molecular Weight:
393.48
Molecular Formula:
C17H27NO2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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U-99194 maleate is a synthetic compound consisting of a maleic acid ester and an aminopropyl group. Widely utilized in scientific research, this small molecule has been employed to investigate various aspects of its potential biological activity and pharmacodynamics. Extensive studies have revealed the diverse biochemical and physiological effects of U-99194 maleate. Research has demonstrated that U-99194 maleate possesses the ability to inhibit gene expression and induce apoptosis in cells. Moreover, its biological activity has been explored in different contexts. For instance, one study focused on the impact of a specific histone modification on gene expression, with U-99194 maleate being employed. Notably, the results highlighted the significant influence of U-99194 maleate on gene expression. Additionally, U-99194 maleate has exhibited anti-inflammatory properties and the capacity to stimulate the immune system, as observed in various studies. Although the precise mechanism of action of U-99194 maleate remains incompletely understood, it is postulated that the compound binds to histone proteins, impeding their interaction with DNA. Consequently, the transcription of specific genes is hindered, leading to a wide array of biological effects.


U 99194 maleate (CAS 234757-41-6) References

  1. Dopamine-mediated disinhibition in the CA1 region of rat hippocampus via D3 receptor activation.  |  Hammad, H. and Wagner, JJ. 2006. J Pharmacol Exp Ther. 316: 113-20. PMID: 16162819
  2. Prototypical antipsychotic drugs protect hippocampal neuronal cultures against cell death induced by growth medium deprivation.  |  Bastianetto, S., et al. 2006. BMC Neurosci. 7: 28. PMID: 16573831
  3. Examining the Effects of Sodium Ions on the Binding of Antagonists to Dopamine D2 and D3 Receptors.  |  Newton, CL., et al. 2016. PLoS One. 11: e0158808. PMID: 27379794

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

U 99194 maleate, 10 mg

sc-204365
10 mg
$101.00

U 99194 maleate, 50 mg

sc-204365A
50 mg
$575.00