TyrRS Antibody (H-11): sc-166741
- TyrRS Antibody (H-11) is a mouse monoclonal IgG2a κ TyrRS antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 448-465 near the C-terminus of TyrRS of human origin
- TyrRS Antibody (H-11) is recommended for detection of TyrRS of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-TyrRS Antibody (H-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TyrRS Antibody (H-11) for WB and IHC(P) applications. These reagents are now offered in bundles with TyrRS Antibody (H-11) (see ordering information below).
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SEE ALSO...
TyrRS Antibody (H-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects TyrRS protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). TyrRS (H-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Tyrosyl-tRNA synthetase (TyrRS) catalyzes tRNA(Tyr) aminoacylation with L-tyrosine, an essential amino acid vital for protein production involved in numerous cellular functions. TyrRS exists as a homodimer for stability and activity, with proper functioning critical for maintaining cellular homeostasis and stress response. TyrRS dysregulation has been implicated in various diseases, including cancer and neurodegenerative disorders, highlighting TyrRS significance as a potential therapeutic target. TyrRS presence in both cytoplasm and mitochondria underscores TyrRS versatile role in cellular metabolism and compartmental interplay.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TyrRS Antibody (H-11) References:
- A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. | Wakasugi, K., et al. 2002. Proc Natl Acad Sci U S A. 99: 173-7. PMID: 11773626
- Expression, purification, and characterization of human tyrosyl-tRNA synthetase. | Jia, J., et al. 2003. Protein Expr Purif. 27: 104-8. PMID: 12509991
- A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase. | Kise, Y., et al. 2004. Nat Struct Mol Biol. 11: 149-56. PMID: 14730354
- Relationship of two human tRNA synthetases used in cell signaling. | Yang, XL., et al. 2004. Trends Biochem Sci. 29: 250-6. PMID: 15130561
- Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. | Bonnefond, L., et al. 2005. Biochemistry. 44: 4805-16. PMID: 15779907
- Human mitochondrial TyrRS disobeys the tyrosine identity rules. | Bonnefond, L., et al. 2005. RNA. 11: 558-62. PMID: 15840810
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TyrRS Antibody (H-11) | sc-166741 | 200 µg/ml | $316.00 | |||
TyrRS Antibody (H-11): m-IgGκ BP-HRP Bundle | sc-521728 | 200 µg Ab, 40 µg BP | $354.00 | |||
TyrRS Antibody (H-11): m-IgG2a BP-HRP Bundle | sc-546103 | 200 µg Ab; 10 µg BP | $354.00 | |||
TyrRS Antibody (H-11) AC | sc-166741 AC | 500 µg/ml, 25% agarose | $416.00 | |||
TyrRS Antibody (H-11) HRP | sc-166741 HRP | 200 µg/ml | $316.00 | |||
TyrRS Antibody (H-11) FITC | sc-166741 FITC | 200 µg/ml | $330.00 | |||
TyrRS Antibody (H-11) PE | sc-166741 PE | 200 µg/ml | $343.00 | |||
TyrRS Antibody (H-11) Alexa Fluor® 488 | sc-166741 AF488 | 200 µg/ml | $357.00 | |||
TyrRS Antibody (H-11) Alexa Fluor® 546 | sc-166741 AF546 | 200 µg/ml | $357.00 | |||
TyrRS Antibody (H-11) Alexa Fluor® 594 | sc-166741 AF594 | 200 µg/ml | $357.00 | |||
TyrRS Antibody (H-11) Alexa Fluor® 647 | sc-166741 AF647 | 200 µg/ml | $357.00 | |||
TyrRS Antibody (H-11) Alexa Fluor® 680 | sc-166741 AF680 | 200 µg/ml | $357.00 | |||
TyrRS Antibody (H-11) Alexa Fluor® 790 | sc-166741 AF790 | 200 µg/ml | $357.00 | |||
TyrRS (H-11) Neutralizing Peptide | sc-166741 P | 100 µg/0.5 ml | $68.00 |