Molecular structure of Tyrphostin AG 1433, CAS Number: 168836-03-1
Tyrphostin AG 1433 (CAS 168836-03-1)
Application:
Tyrphostin AG 1433 is an inhibitor of PDGFR-β, Flk-1, and angiogenesis
CAS Number:
168836-03-1
Purity:
≥95%
Molecular Weight:
266.29
Molecular Formula:
C16H14N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Tyrphostin AG 1433 is a specific and potent inhibitor of PDGF-b receptor kinase (IC50 = 5.0 µM) and of KDR/Flk-1/VEGF Receptor 2 (IC50 = 9.3 µM). Also acts as angiogenesis inhibitor.
Tyrphostin AG 1433 (CAS 168836-03-1) References
- An HTS approach to screen for antagonists of the nuclear export machinery using high content cell-based assays. | Zanella, F., et al. 2007. Assay Drug Dev Technol. 5: 333-41. PMID: 17638533
- Chemical genetic analysis of FOXO nuclear-cytoplasmic shuttling by using image-based cell screening. | Zanella, F., et al. 2008. Chembiochem. 9: 2229-37. PMID: 18756565
- Elucidation of crucial structures for a catechol-based inhibitor of plasma hyaluronan-binding protein (factor VII activating protease) autoactivation. | Yamamoto, E., et al. 2011. Biosci Biotechnol Biochem. 75: 2070-2. PMID: 21979097
- Flk-1 as a target for tumor growth inhibition. | Strawn, LM., et al. 1996. Cancer Res. 56: 3540-5. PMID: 8758924
- The vascular endothelial growth factor receptor KDR activates multiple signal transduction pathways in porcine aortic endothelial cells. | Kroll, J. and Waltenberger, J. 1997. J Biol Chem. 272: 32521-7. PMID: 9405464
Inhibitor of:
Angiogenesis, Flk-1, and PDGFR-beta.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrphostin AG 1433, 1 mg | sc-205984 | 1 mg | $48.00 | |||
Tyrphostin AG 1433, 5 mg | sc-205984A | 5 mg | $200.00 |