TREK-2 Antibody (1C1): sc-293332

TREK-2 Antibody (1C1) is a mouse monoclonal IgG1 kappa light chain antibody that detects the TREK-2 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-TREK-2 antibody (1C1) is available as a non-conjugated monoclonal isotype antibody. TREK-2, also known as TWIK-related K+ channel 2, is a member of the tandem-pore potassium channel family, which plays a crucial role in maintaining the resting membrane potential and regulating cellular excitability. TREK-2 monoclonal antibody (1C1) targets a protein particularly important in the central nervous system, where TREK-2 contributes to neuronal signaling and the modulation of synaptic transmission. TREK-2 is primarily localized in the cerebellum, spleen, and testis, and TREK-2′s expression in these tissues underscores its significance in various physiological processes, including sensory transduction and the response to mechanical stimuli. TREK-2 consists of 538 amino acids and features two pore-forming domains and four transmembrane segments, which are essential for its function as a potassium channel. TREK-2 exhibits inward rectification and is activated by arachidonic acid and other unsaturated fatty acids, highlighting TREK-2′s role in cellular responses to metabolic changes. With a 65% amino acid sequence identity to TREK-1, TREK-2′s unique properties and tissue distribution make TREK-2 a valuable target for research in neurobiology and related fields.

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TREK-2 Antibody (1C1) References:

1. TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family.  |  Bang, H., et al. 2000. J Biol Chem. 275: 17412-9. PMID: 10747911
2. Molecular biology of voltage-dependent potassium channels.  |  Pongs, O. 1992. Physiol Rev. 72: S69-88. PMID: 1438587
3. Potassium channels and their evolving gates.  |  Jan, LY. and Jan, YN. 1994. Nature. 371: 119-22. PMID: 8072541
4. Eight potassium channel families revealed by the C. elegans genome project.  |  Wei, A., et al. 1996. Neuropharmacology. 35: 805-29. PMID: 8938713
5. Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.  |  Fink, M., et al. 1996. EMBO J. 15: 6854-62. PMID: 9003761
6. A mammalian two pore domain mechano-gated S-like K+ channel.  |  Patel, AJ., et al. 1998. EMBO J. 17: 4283-90. PMID: 9687497
7. TRAAK is a mammalian neuronal mechano-gated K+ channel.  |  Maingret, F., et al. 1999. J Biol Chem. 274: 1381-7. PMID: 9880510

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TREK-2 Antibody (1C1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TREK-2 Antibody (1C1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TREK-2 Antibody (1C1) Specifications

Alternate Product Name: TREK-2

Product Clone Name: 1C1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 439-538

Epitope Target: TREK-2

Epitope Species: human

Product Reactivity/Detection: TREK-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TREK-2 Antibody (1C1): N/A