Toso Antibody (RR-16): sc-101253

Toso Antibody (RR-16) is a mouse monoclonal IgG2b kappa light chain antibody that detects the Toso protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Toso antibody (RR-16) is available as the non-conjugated form. Toso (RR-16) antibody recognizes a protein that plays a crucial role in regulating apoptosis, particularly in the context of cytotoxic T lymphocyte (CTL)-mediated immune responses. By blocking apoptosis induced by members of the tumor necrosis factor (TNF) family, including FAS, Toso (RR-16) monoclonal antibody targets a protein essential for maintaining T cell survival during immune activation. This function is particularly important as it allows CTLs to effectively target and eliminate virus-infected or transformed cells without undergoing self-destruction. Toso (RR-16) antibody detects a protein expressed on the surface of various lymphoid cells, where it interacts with FAS and its ligand, thereby modulating the apoptotic signals that would otherwise lead to T cell death. Understanding Toso′s role in these processes not only highlights its significance in immune regulation but also suggests its potential as a therapeutic target in diseases characterized by dysregulated apoptosis, such as cancer and autoimmune disorders.

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Toso Antibody (RR-16) References:

1. Role of perforin in lymphocyte-mediated cytolysis.  |  Yagita, H., et al. 1992. Adv Immunol. 51: 215-42. PMID: 1502975
2. A central role of perforin in cytolysis?  |  Podack, ER., et al. 1991. Annu Rev Immunol. 9: 129-57. PMID: 1910674
3. Mechanism of lymphocyte-mediated cytotoxicity.  |  Henkart, PA. 1985. Annu Rev Immunol. 3: 31-58. PMID: 3904772
4. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family.  |  Suda, T., et al. 1993. Cell. 75: 1169-78. PMID: 7505205
5. Fas and its ligand in a general mechanism of T-cell-mediated cytotoxicity.  |  Hanabuchi, S., et al. 1994. Proc Natl Acad Sci U S A. 91: 4930-4. PMID: 7515183
6. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.  |  Kägi, D., et al. 1994. Science. 265: 528-30. PMID: 7518614
7. The Fas protein is expressed at high levels on CD4+CD8+ thymocytes and activated mature lymphocytes in normal mice but not in the lupus-prone strain, MRL lpr/lpr.  |  Drappa, J., et al. 1993. Proc Natl Acad Sci U S A. 90: 10340-4. PMID: 7694292
8. Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells.  |  Hitoshi, Y., et al. 1998. Immunity. 8: 461-71. PMID: 9586636

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Toso Antibody (RR-16) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Toso Antibody (RR-16) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Toso Antibody (RR-16) Specifications

Alternate Product Name: Toso

Product Clone Name: RR-16

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 124-223

Epitope Target: Toso

Epitope Species: human

Product Reactivity/Detection: Toso

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Toso Antibody (RR-16): N/A