TNF-R1 Antibody (55R-170): sc-12746
- TNF-R1 Antibody (55R-170) is a Armenian hamster monoclonal IgG, cited in 14 publications, provided at 200 µg/ml
- raised against purified extracellular domain of TNF-R1 of mouse origin
- recommended for detection of TNF-R1 of mouse, rat and human origin by IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for neutralization, sc-12746 L, 200 µg/0.1 ml
- See TNF-R1 (H-5): sc-8436 for TNF-R1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TNF-R1 Antibody (55R-170). This work is in progress.
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TNF-R1 Antibody (55R-170) is a hamster monoclonal IgG antibody that detects tumor necrosis factor receptor 1 (TNF-R1) in mouse, rat, and human samples through applications such as immunoprecipitation (IP) and flow cytometry (FCM). TNF-R1 plays a crucial role in mediating the effects of tumor necrosis factor, a key cytokine involved in inflammation and immune responses. TNF-R1 is primarily located on the surface of various cell types, including immune cells, where TNF-R1 initiates signaling pathways that can lead to cell survival, proliferation, or apoptosis, depending on the context. TNF-R1′s ability to transduce apoptotic signals is particularly important in regulating immune responses and maintaining tissue homeostasis. Dysregulation of TNF-R1 signaling has been implicated in numerous diseases, including autoimmune disorders and cancer, making TNF-R1 a significant target for therapeutic intervention. TNF-R1 monoclonal antibody (55R-170) is designed to provide reliable detection and characterization of this vital receptor, facilitating research into its role in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TNF-R1 Antibody (55R-170) References:
- Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling. | Schütze, S. and Schneider-Brachert, W. 2009. Results Probl Cell Differ. 49: 63-85. PMID: 19132322
- TNF/TNF-R1 pathway is involved in doxorubicin-induced acute sterile inflammation. | Kaczmarek, A., et al. 2013. Cell Death Dis. 4: e961. PMID: 24336081
- TNF-R1 as a first trimester marker for prediction of pre-eclampsia. | E Holanda Moura, SB., et al. 2016. J Matern Fetal Neonatal Med. 29: 897-903. PMID: 25758630
- Molecular dynamics and intracellular signaling of the TNF-R1 with the R92Q mutation. | Agulló, L., et al. 2015. J Neuroimmunol. 289: 12-20. PMID: 26616867
- TNF-R1 and FADD mediate UVB-Induced activation of K+ channels in corneal epithelial cells. | Boersma, PM., et al. 2017. Exp Eye Res. 154: 1-9. PMID: 27818316
- TNF-alpha and TNF-R1 regulate bupivacaine-induced apoptosis in spinal cord dorsal root ganglion neuron. | Zhang, K., et al. 2018. Eur J Pharmacol. 833: 63-68. PMID: 29802833
- Venous and arterial TNF-R1 predicts outcome and complications in acute subarachnoid hemorrhage. | Fragata, I., et al. 2019. Neurocrit Care. 31: 107-115. PMID: 30673997
- Downregulation of TNF-α/TNF-R1 Signals by AT-Lipoxin A4 May Be a Significant Mechanism of Attenuation in SAP-Associated Lung Injury. | Yu, S., et al. 2019. Mediators Inflamm. 2019: 9019404. PMID: 31097921
- Differences in TNF‑α and TNF‑R1 expression in damaged neurons and activated astrocytes of the hippocampal CA1 region between young and adult gerbils following transient forebrain ischemia. | Lee, CH., et al. 2021. Mol Med Rep. 24: PMID: 34212986
- Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells. | Fritsch, J., et al. 2021. Cells. 10: PMID: 34831323
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TNF-R1 Antibody (55R-170) | sc-12746 | 200 µg/ml | $322.00 | |||
TNF-R1 Antibody (55R-170) FITC | sc-12746 FITC | 200 µg/ml | $336.00 | |||
TNF-R1 Antibody (55R-170) L | sc-12746 L | 200 µg/0.1 ml | $322.00 | |||
TNF-R1 Antibody (55R-170) PE | sc-12746 PE | 200 µg/ml | $349.00 |