TLX3 Antibody (34-L): sc-81990
- TLX3 Antibody (34-L) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant TLX3 of human origin
- recommended for detection of TLX3 of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TLX3 Antibody (34-L). This work is in progress.
QUICK LINKS
TLX3 Antibody (34-L) is a mouse monoclonal IgG1 antibody that detects TLX3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). TLX3 plays a crucial role in the development of the central nervous system, particularly in the formation of first-order relay visceral sensory neurons in the brainstem, which are essential for processing sensory information and regulating autonomic functions. Anti-TLX3 antibody (34-L) enables research into TLX3′s vital functions, as deficiency leads to severe respiratory issues in newborn mice, including increased respiration rates and frequent apnea, ultimately resulting in central respiratory failure shortly after birth. Additionally, TLX3 is implicated in T-cell acute lymphoblastic leukemia (T-ALL), where the t(5:14)(q35;q32) translocation enhances transcription, highlighting significance not only in developmental biology but also in cancer research. TLX3 monoclonal antibody (34-L) serves as an invaluable tool for researchers studying TLX3′s intricate roles in both normal physiology and disease states, providing insights into function and potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TLX3 Antibody (34-L) References:
- Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells. | Kondo, T., et al. 2008. Proc Natl Acad Sci U S A. 105: 5780-5. PMID: 18391221
- The effect of TLX3 expression on the prognosis of pediatric T cell acute lymphocytic leukemia--a systematic review. | Ma, J., et al. 2014. Tumour Biol. 35: 8439-43. PMID: 24997618
- Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP. | Shimomura, A., et al. 2015. PLoS One. 10: e0135060. PMID: 26258652
- TLX3 repressed SNAI1-induced epithelial-mesenchymal transition by directly constraining STAT3 phosphorylation and functionally sensitized 5-FU chemotherapy in hepatocellular carcinoma. | Wang, C., et al. 2019. Int J Biol Sci. 15: 1696-1711. PMID: 31360112
- Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord. | Monteiro, FA., et al. 2021. Front Cell Dev Biol. 9: 642697. PMID: 33996801
- T-Cell Acute Lymphoblastic Leukemia: Biomarkers and Their Clinical Usefulness. | Bardelli, V., et al. 2021. Genes (Basel). 12: PMID: 34440292
- Tlx3 controls the development of C-low threshold mechanoreceptors. | Wang, H., et al. 2022. Neuroreport. 33: 617-622. PMID: 36062515
- T/myeloid mixed phenotype acute leukaemia harbouring TLX3::BCL11B with TLX3 activation. | Botten, GA., et al. 2024. Br J Haematol. 205: 607-612. PMID: 38385580
- Tlx3 mediates neuronal differentiation and proper condensation of the developing trigeminal ganglion. | Urrutia, HA., et al. 2024. Dev Biol. 515: 79-91. PMID: 39019425
- TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism. | Parvathy, S., et al. 2024. iScience. 27: 111260. PMID: 39628587
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TLX3 Antibody (34-L) | sc-81990 | 100 µg/ml | $339.00 |