TIN2 Antibody (59B388): sc-52960
- TIN2 Antibody (59B388) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against amino acids 44-58 of TIN2 of human origin
- recommended for detection of TIN2 of mouse, rat and human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TIN2 Antibody (59B388). This work is in progress.
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SEE ALSO...
TIN2 Antibody (59B388) is a mouse monoclonal IgG1 antibody that detects TIN2 in mouse, rat, and human samples through western blotting (WB). TIN2, or TRF1-interacting nuclear factor 2, plays a crucial role in telomere maintenance by acting as a bridge between the telomeric proteins TRF1 and TRF2, thereby regulating telomere length and stability. TIN2 is primarily located in the nucleus, where TIN2 associates with telomeres, ensuring that the protective caps at the ends of chromosomes remain intact and functional. TIN2′s nuclear localization is essential for the proper assembly of the shelterin complex, which protects telomeres from being recognized as DNA damage. Disruption of TIN2 function can lead to telomere shortening and genomic instability, which are hallmarks of various age-related diseases and cancers. Anti-TIN2 antibody (59B388) enables researchers to gain valuable insights into the mechanisms of telomere biology and its implications in cellular aging and tumorigenesis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TIN2 Antibody (59B388) | sc-52960 | 100 µg/ml | $339.00 |