Thielavin B (CAS 71950-67-9)
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Thielavin B is a macrocyclic lactone compound with reported antifungal and antibacterial properties, making it a subject of interest in microbiological research. It is studied for its ability to inhibit the synthesis of bacterial cell walls and fungal cell membranes, providing insights into potential mechanisms for combating microbial infections in agricultural settings. In organic chemistry, Thielavin B serves as a model compound for the study of macrocyclic lactone synthesis and the exploration of structure-activity relationships. Its complex molecular architecture also makes it a candidate for chemical biology studies aiming to understand the interaction between natural products and biological macromolecules. Environmental scientists may analyze the compound′s natural occurrence, biosynthesis, and degradation within ecosystems, contributing to a broader understanding of the ecological roles of secondary metabolites.
Thielavin B (CAS 71950-67-9) References
- Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B. | Togashi, K., et al. 2001. Biosci Biotechnol Biochem. 65: 651-3. PMID: 11330682
- Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activities. | Sakemi, S., et al. 2002. J Antibiot (Tokyo). 55: 941-51. PMID: 12546415
- Screening strategies for discovery of antibacterial natural products. | Singh, SB., et al. 2011. Expert Rev Anti Infect Ther. 9: 589-613. PMID: 21819327
- Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales. | Ayers, S., et al. 2011. Tetrahedron Lett. 52: 5733-5735. PMID: 22566715
- Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia. | Loutet, SA., et al. 2015. Int J Antimicrob Agents. 46: 376-80. PMID: 26187366
- Mechanism Behind the Programmed Biosynthesis of Heterotrimeric Fungal Depside Thielavin A. | Ji, Q., et al. 2024. Angew Chem Int Ed Engl. 63: e202402663. PMID: 38467568
- The structures of thielavins A, B and C. Prostaglandin synthetase inhibitors from fungi. | Kitahara, N., et al. 1983. J Antibiot (Tokyo). 36: 599-600. PMID: 6409872
- Thielavin A and B, new inhibitors of prostaglandin biosynthesis produced by Thielavia terricola. | Kitahara, N., et al. 1981. J Antibiot (Tokyo). 34: 1562-8. PMID: 7333968
- Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus. | Mani, N., et al. 1998. J Antibiot (Tokyo). 51: 471-9. PMID: 9666175
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Thielavin B, 500 µg | sc-202362 | 500 µg | $307.00 |