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Prostaglandin D2 (PGD2) is synthesized by hematopoietic-type PGD-synthase (H-PGDS) in mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.1 PGD2 is also produced in the brain by lipocalin PGD-synthase also known as β-trace.2,3 In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.2,3 Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.4 tetranor-PGDM is a major metabolite of PGD2 that is detectable in human and murine urine.5 tetranor-PGDM was detected in murine urine at a level of 8.1 ± 1.3 ng/mg creatinine.5
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
tetranor-PGDM, 25 µg | sc-205522 | 25 µg | $255.00 | |||
tetranor-PGDM, 100 µg | sc-205522A | 100 µg | $910.00 |