Date published: 2026-4-27

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Tetramethylthiourea (CAS 2782-91-4)

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CAS Number:
2782-91-4
Molecular Weight:
132.23
Molecular Formula:
C5H12N2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Tetramethylthiourea (TMU) is an organosulfur compound characterized by four methyl groups bonded to a thiourea molecule. Its appearance is that of a colorless solid, and it dissolves easily in both water and alcohols. This versatile compound finds extensive use in various applications, including organic synthesis, acting as a laboratory reagent. Additionally, Tetramethylthiourea plays a significant part in the synthesis of polymers and diverse materials. It demonstrates its effectiveness in synthesizing a wide array of organic compounds. Notably, it has been instrumental in the creation of essential components utilized in research. Moreover, Tetramethylthiourea′s application extends to the synthesis of materials utilized production. An essential aspect of Tetramethylthiourea lies in its role as a nucleophile, enabling it to form covalent bonds when interacting with other molecules. In the presence of an electrophile, like an alkyl halide, this compound can generate a thiourea derivative. Known as a nucleophilic substitution reaction, this process forms the basis for numerous reactions involving Tetramethylthiourea. Its unique properties and versatility make it an indispensable component in various scientific and industrial endeavors.


Tetramethylthiourea (CAS 2782-91-4) References

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  2. An electrochemical quartz crystal microbalance study of the etching of gold surfaces in the presence of tetramethylthiourea.  |  Larsen, AG., et al. 2004. J Colloid Interface Sci. 279: 158-66. PMID: 15380425
  3. DNA-binding activity of NF-kappaB and phosphorylation of p65 are induced by N-acetylcysteine through phosphatidylinositol (PI) 3-kinase.  |  Liu, J., et al. 2008. Mol Immunol. 45: 3984-9. PMID: 18657320
  4. Mixed adsorption layers of 0.1 M tert-butanol-tetramethylthiourea at the interface of Hg/aqueous perchlorate solutions.  |  Gugała-Fekner, D., et al. 2009. J Colloid Interface Sci. 332: 291-7. PMID: 19185313
  5. Platinum(II) mediated C(sp3)-H activation of tetramethylthiourea.  |  Fantasia, S., et al. 2009. Dalton Trans. 8107-10. PMID: 19771375
  6. S-oxygenation of thiocarbamides IV: Kinetics of oxidation of tetramethylthiourea by aqueous bromine and acidic bromate.  |  Ajibola, RO. and Simoyi, RH. 2011. J Phys Chem A. 115: 2735-44. PMID: 21401032
  7. Methylthioureas and their morpholine and dioxane adducts; hydrogen-bonding patterns.  |  Jones, PG., et al. 2013. Acta Crystallogr B Struct Sci Cryst Eng Mater. 69: 405-13. PMID: 23873066
  8. Efficient dye-sensitized solar cells using a tetramethylthiourea redox mediator.  |  Liu, Y., et al. 2013. ChemSusChem. 6: 2124-31. PMID: 23929783
  9. The Adsorption of Tetramethylthiourea at the Interface Electrode - NaClO4 in the Presence of Sodium 1-decanesulfonate.  |  Klin, M., et al. 2011. Acta Chim Slov. 58: 26-32. PMID: 24061939
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  11. Oxyhalogen-Sulfur Chemistry: Kinetics and Mechanism of Oxidation of 1,3-Dimethylthiourea by Acidic Bromate.  |  Olagunju, O. and Simoyi, RH. 2017. J Phys Chem A. 121: 6366-6376. PMID: 28793188
  12. Virtual Screening Guided Design, Synthesis and Bioactivity Study of Benzisoselenazolones (BISAs) on Inhibition of c-Met and Its Downstream Signalling Pathways.  |  Zhang, S., et al. 2019. Int J Mol Sci. 20: PMID: 31137515
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  14. Embryotoxicity of industrial chemicals on the chicken embryo: thiourea derivatives.  |  Korhonen, A., et al. 1982. Acta Pharmacol Toxicol (Copenh). 51: 38-44. PMID: 6812389

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Tetramethylthiourea, 25 g

sc-251205
25 g
$48.00