Telethonin Antibody (53): sc-136097
- Telethonin Antibody (53) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 1-167 representing full length Telethonin of mouse origin
- recommended for detection of Telethonin of mouse, rat and human origin by WB and IP
- See Telethonin (G-11): sc-25327 for Telethonin antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Telethonin Antibody (53). This work is in progress.
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Telethonin Antibody (53) is a mouse monoclonal IgG1 antibody that detects telethonin in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. Telethonin plays a crucial role in muscle function by stabilizing the structure of the sarcomere, which is essential for muscle contraction and overall muscle integrity. Telethonin is primarily located in the Z-disc of striated muscle fibers, where anti-telethonin antibody (53) can detect interactions with titin and other sarcomeric proteins that maintain the organization and elasticity of the myofibrils. Proper localization of telethonin is vital, as any disruption can lead to muscle diseases such as dilated cardiomyopathy and skeletal myopathies. By facilitating the assembly and maintenance of the sarcomere, telethonin ensures that muscle fibers can contract efficiently and respond to physiological demands. Telethonin monoclonal antibody (53) serves as an invaluable tool for researchers studying muscle biology and related disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Telethonin Antibody (53) References:
- Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin. | Moreira, ES., et al. 2000. Nat Genet. 24: 163-6. PMID: 10655062
- Telethonin protein expression in neuromuscular disorders. | Vainzof, M., et al. 2002. Biochim Biophys Acta. 1588: 33-40. PMID: 12379311
- Solution scattering suggests cross-linking function of telethonin in the complex with titin. | Zou, P., et al. 2003. J Biol Chem. 278: 2636-44. PMID: 12446666
- Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus. | Pinotsis, N., et al. 2006. J Struct Biol. 155: 239-50. PMID: 16713295
- The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. | Bertz, M., et al. 2009. Proc Natl Acad Sci U S A. 106: 13307-133310. PMID: 19622741
- Distinct roles for telethonin N-versus C-terminus in sarcomere assembly and maintenance. | Sadikot, T., et al. 2010. Dev Dyn. 239: 1124-35. PMID: 20235223
- A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart. | Ibrahim, M., et al. 2013. Hum Mol Genet. 22: 372-83. PMID: 23100327
- Conserved expression of truncated telethonin in a patient with limb-girdle muscular dystrophy 2G. | Barresi, R., et al. 2015. Neuromuscul Disord. 25: 349-52. PMID: 25724973
- Telethonin, a novel sarcomeric protein of heart and skeletal muscle. | Valle, G., et al. 1997. FEBS Lett. 415: 163-8. PMID: 9350988
- Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin. | Mues, A., et al. 1998. FEBS Lett. 428: 111-4. PMID: 9645487
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Telethonin Antibody (53) | sc-136097 | 50 µg/0.5 ml | $322.00 |