TCR V α 8 Antibody (3H3002): sc-73132

TCR V α 8 Antibody (3H3002) is a rat monoclonal IgG2a antibody that detects T cell antigen receptor (TCR) in mouse samples through immunofluorescence (IF) and flow cytometry (FCM) applications. TCR V α 8 is crucial for the immune response as TCR V α 8 plays a significant role in recognizing a diverse array of foreign antigens, which is essential for the activation of T cells. TCR is a heterodimer that can be composed of either α and β or γ and δ chains, with the majority of circulating T cells (approximately 95%) expressing the α/β heterodimer. The ability of TCR to recognize various antigens is facilitated by the somatic recombination of variable (V), diversity (D), and joining (J) gene segments during TCR chain assembly, allowing for a vast repertoire of specificities. TCR β and γ chain genes are located in distinct loci, while the genes for TCR α and δ chains are found within a single locus, with the assembled TCR α chain comprising only V and J segments. In mice, there are about 104 V α segments and 61 J α segments at the α/δ loci, while humans have approximately half as many V α segments but a similar number of J α segments. Anti-TCR V α 8 antibody (3H3002) is an invaluable tool for researchers studying T cell activation and immune responses, providing insights into the complex mechanisms of antigen recognition and T cell differentiation.

The preferred TCR V α 8 antibody is TCR V α 8 Antibody (KT50): sc-53477.