TCR α/β Antibody (6A466): sc-73121
- TCR α/β Antibody (6A466) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- immunized with rat T blasts and rat erythrocytes
- recommended for detection of TCR α/β of mouse and rat origin by WB, IP, IF, IHC(P) and FCM
- m-IgGκ BP-HRP is the preferred secondary detection reagent for TCR α/β Antibody (6A466) for WB and IHC(P) applications. This reagent is now offered in a bundle with TCR α/β Antibody (6A466) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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TCR α/β Antibody (6A466) is a mouse monoclonal IgG1 antibody that detects T cell antigen receptor (TCR) in mouse and rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-TCR α/β antibody (6A466) specifically recognizes TCR, which plays a crucial role in the immune response by recognizing foreign antigens and initiating intracellular signaling that leads to T cell activation. TCR is a heterodimer composed predominantly of α and β chains, with approximately 95% of circulating T cells expressing this α/β form, while a smaller subset expresses the γ/δ heterodimer. TCR presence on T helper and T cytotoxic cells, distinguished by their expression of CD4 and CD8 co-receptors, is essential for effective immune responses. TCR α/β (6A466) monoclonal antibody interacts with class II major histocompatibility complex (MHC) molecules presented by antigen-presenting cells, and binding is enhanced by CD4 protein, which increases the avidity of the interaction. This interaction is vital for the activation of T helper cells, which are crucial for orchestrating the adaptive immune response, making TCR a key target for studies related to immunology and therapeutic interventions.
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TCR α/β Antibody (6A466) References:
- The amplification of TCR signaling by dynamic membrane microdomains. | Viola, A. 2001. Trends Immunol. 22: 322-7. PMID: 11377292
- Initiation of TCR signalling revisited. | Trautmann, A. and Randriamampita, C. 2003. Trends Immunol. 24: 425-8. PMID: 12909455
- TCR and Notch synergize in alphabeta versus gammadelta lineage choice. | Garbe, AI. and von Boehmer, H. 2007. Trends Immunol. 28: 124-31. PMID: 17261380
- T cell receptor (TCR) gene therapy to treat melanoma: lessons from clinical and preclinical studies. | Coccoris, M., et al. 2010. Expert Opin Biol Ther. 10: 547-62. PMID: 20146634
- Reconstitution of TCR Signaling Using Supported Lipid Bilayers. | Su, X., et al. 2017. Methods Mol Biol. 1584: 65-76. PMID: 28255696
- Early TCR Signaling Sweetens Effector Function through PDHK1. | Weisshaar, N., et al. 2018. Trends Endocrinol Metab. 29: 595-597. PMID: 29615303
- Cytokines enhance human Vγ9Vδ2 T-cell TCR-dependent and TCR-independent effector functions. | Field, KR., et al. 2023. Eur J Immunol. 53: e2250220. PMID: 36946072
- TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer. | Okamoto, M. and Yamamoto, M. 2024. Adv Exp Med Biol. 1444: 177-193. PMID: 38467980
- TCR V gene usage in autoimmunity. | Gold, DP. 1994. Curr Opin Immunol. 6: 907-12. PMID: 7536011
- TCR peptide therapy in autoimmune diseases. | Vandenbark, AA., et al. 1993. Int Rev Immunol. 9: 251-76. PMID: 7683708
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCR α/β Antibody (6A466) | sc-73121 | 200 µg/ml | $322.00 | |||
TCR α/β Antibody (6A466): m-IgGκ BP-HRP Bundle | sc-534427 | 200 µg Ab; 40 µg BP | $361.00 |