TCP-1 β Antibody (D-5): sc-374153
- TCP-1 β Antibody (D-5) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 456-535 mapping at the C-terminus of TCP-1 β of human origin
- recommended for detection of TCP-1 β of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgG2b BP-HRP is the preferred secondary detection reagent for TCP-1 β Antibody (D-5) for WB and IHC(P) applications. This reagent is now offered in a bundle with TCP-1 β Antibody (D-5) (see ordering information below).
TCP-1 β Antibody (D-5) is a mouse monoclonal IgG2b antibody that detects TCP-1 β in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). TCP-1 β is a crucial subunit of the chaperonin containing TCP-1 (CCT) complex, which is essential for the proper folding of cytosolic proteins, particularly actins and tubulins. The CCT complex is composed of eight distinct subunits, each encoded by different genes, and TCP-1 β (D-5) antibody targets a key component responsible for ensuring proteins achieve their functional conformations, vital for maintaining cellular structure and function. The proper folding of actins and tubulins is critical for various cellular processes, including cytoskeletal dynamics, cell motility, and intracellular transport. Dysregulation of TCP-1 β or associated pathways can lead to a range of diseases, including neurodegenerative disorders and cancer, highlighting TCP-1 β′s importance in both health and disease. Anti-TCP-1 β antibody (D-5) serves as an invaluable tool for researchers studying molecular mechanisms underlying protein folding and their implications in various biological contexts.
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TCP-1 β Antibody (D-5) References:
- Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis. | Wang, Q., et al. 2019. Vet Microbiol. 235: 151-163. PMID: 31282373
- TSPAN31 regulates the proliferation, migration, and apoptosis of gastric cancer cells through the METTL1/CCT2 pathway. | Ma, X., et al. 2022. Transl Oncol. 20: 101423. PMID: 35429902
- Comprehensive prognostic and immunological analysis of CCT2 in pan-cancer. | Lv, W., et al. 2022. Front Oncol. 12: 986990. PMID: 36119498
- Multi-omics analysis revealed the role of CCT2 in the induction of autophagy in Alzheimer's disease. | Ma, X., et al. 2022. Front Genet. 13: 967730. PMID: 36704351
- PRRSV degrades MDA5 via dual autophagy receptors P62 and CCT2 to evade antiviral innate immunity. | Sun, R., et al. 2024. Virol Sin. 39: 264-276. PMID: 38272236
- Targeting the molecular chaperone CCT2 inhibits GBM progression by influencing KRAS stability. | Zhao, F., et al. 2024. Cancer Lett. 590: 216844. PMID: 38582394
- Compound heterozygous mutations in a mouse model of Leber congenital amaurosis reveal the role of CCT2 in photoreceptor maintenance. | Suga, A., et al. 2024. Commun Biol. 7: 676. PMID: 38830954
- Trim21-mediated CCT2 ubiquitination suppresses malignant progression and promotes CD4+T cell activation in breast cancer. | Chen, X., et al. 2024. Cell Death Dis. 15: 542. PMID: 39079960
- Two distinct regulatory pathways govern Cct2-Atg8 binding in the process of solid aggrephagy. | Chen, Y., et al. 2024. EMBO Rep. 25: 4749-4776. PMID: 39322741
- The essential role of CCT2 in the regulation of aggrephagy. | Luo, J., et al. 2024. Front Aging Neurosci. 16: 1491001. PMID: 39478698
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TCP-1 β Antibody (D-5) | sc-374153 | 200 µg/ml | $322.00 | |||
TCP-1 β Antibody (D-5): m-IgG2b BP-HRP Bundle | sc-548568 | 200 µg Ab; 10 µg BP | $361.00 |