TAUT Antibody (E-10): sc-166640
- TAUT Antibody (E-10) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 397-424 within an internal region of TAUT of human origin
- recommended for detection of TAUT of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for TAUT Antibody (E-10) for WB applications. These reagents are now offered in bundles with TAUT Antibody (E-10) (see ordering information below).
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TAUT Antibody (E-10) is a mouse monoclonal IgG1 antibody that detects taurine transporter (TAUT) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TAUT is a crucial multi-pass membrane protein that facilitates taurine uptake, an abundant organic osmolyte known for antioxidant and immunomodulatory properties, playing a significant role in maintaining cell volume homeostasis. TAUT (E-10) antibody helps researchers study intracellular taurine levels, which are essential for various cellular processes, including osmoregulation and calcium signaling modulation. TAUT expression increases with tumor necrosis factor-alpha (TNFα), while phosphorylation at Serine 322 decreases expression, highlighting complex regulatory mechanisms. TAUT overexpression protects renal cells against cisplatin-induced nephrotoxicity, suggesting therapeutic potential in kidney-related disorders. Anti-TAUT antibody (E-10) serves as a valuable tool for investigating taurine transport roles in various biological contexts.
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TAUT Antibody (E-10) References:
- Disruption of the taurine transporter gene (taut) leads to retinal degeneration in mice. | Heller-Stilb, B., et al. 2002. FASEB J. 16: 231-3. PMID: 11772953
- Downregulation of the taurine transporter TauT during hypo-osmotic stress in NIH3T3 mouse fibroblasts. | Hansen, DB., et al. 2012. J Membr Biol. 245: 77-87. PMID: 22383044
- Expression of taurine transporter (TauT) is modulated by heat shock factor 1 (HSF1) in motor neurons of ALS. | Jung, MK., et al. 2013. Mol Neurobiol. 47: 699-710. PMID: 23180277
- Reduced placental taurine transporter (TauT) activity in pregnancies complicated by pre-eclampsia and maternal obesity. | Desforges, M., et al. 2013. Adv Exp Med Biol. 776: 81-91. PMID: 23392873
- Interaction of GABA-mimetics with the taurine transporter (TauT, Slc6a6) in hyperosmotic treated Caco-2, LLC-PK1 and rat renal SKPT cells. | Rasmussen, RN., et al. 2016. Eur J Pharm Sci. 82: 138-46. PMID: 26631583
- Identification of competitive inhibitors of the human taurine transporter TauT in a human kidney cell line. | Richter, M., et al. 2019. Pharmacol Rep. 71: 121-129. PMID: 30612046
- Taurine transporter (TauT) deficiency impairs ammonia detoxification in mouse liver. | Qvartskhava, N., et al. 2019. Proc Natl Acad Sci U S A. 116: 6313-6318. PMID: 30862735
- Effect of Aging on Taurine Transporter (TauT) Expression in the Mouse Brain Cortex. | Neog, MK., et al. 2019. Adv Exp Med Biol. 1155: 3-11. PMID: 31468381
- Targeting Taurine Transporter (TauT) for Cancer Immunotherapy of p53 Mutation Mediated Cancers - Molecular Basis and Preclinical Implication. | Han, X. 2019. Adv Exp Med Biol. 1155: 543-553. PMID: 31468430
- Taurine and its transporter TAUT positively affect male reproduction and early embryo development. | Wu, H., et al. 2022. Hum Reprod. 37: 1229-1243. PMID: 35526154
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TAUT Antibody (E-10) | sc-166640 | 200 µg/ml | $316.00 | |||
TAUT Antibody (E-10): m-IgG Fc BP-HRP Bundle | sc-540136 | 200 µg Ab; 10 µg BP | $354.00 | |||
TAUT Antibody (E-10): m-IgG1 BP-HRP Bundle | sc-541927 | 200 µg Ab; 20 µg BP | $354.00 | |||
TAUT (E-10) Neutralizing Peptide | sc-166640 P | 100 µg/0.5 ml | $68.00 |