Date published: 2025-9-15

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T-705RTP Sodium Salt (CAS 356783-10-3)

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Alternate Names:
6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo-2-pyrazinecarboxamide; 6-Fluoro-3,4-dihydro-4-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-3-oxo--pyrazinecarboxamide
CAS Number:
356783-10-3
Molecular Weight:
552.14
Molecular Formula:
C10H15FN3O15P3•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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T-705RTP Sodium Salt is the triphosphate form of favipiravir, an active metabolite for its antiviral activity, primarily through the inhibition of RNA-dependent RNA polymerase (RdRp). Upon entry into the cell, enzymes convert favipiravir into this triphosphate derivative, which mimics the nucleotides used by viral polymerases. This mimicry allows T-705RTP to be incorporated into the viral RNA, resulting in premature termination of the viral polymerase activity and thus halting viral replication. This specific action makes it useful in virological research, particularly in the study of RNA viruses. By providing a mechanism to directly interfere with the viral replication process, T-705RTP Sodium Salt facilitates the exploration of viral pathogenesis and the screening of antiviral properties in various viral strains under controlled laboratory conditions.


T-705RTP Sodium Salt (CAS 356783-10-3) References

  1. Mechanism of action of T-705 against influenza virus.  |  Furuta, Y., et al. 2005. Antimicrob Agents Chemother. 49: 981-6. PMID: 15728892
  2. Recent advances in antiviral nucleoside and nucleotide therapeutics.  |  Simons, C., et al. 2005. Curr Top Med Chem. 5: 1191-203. PMID: 16305526
  3. Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents.  |  Morrey, JD., et al. 2008. Antiviral Res. 80: 377-9. PMID: 18762216
  4. T-705 (favipiravir) activity against lethal H5N1 influenza A viruses.  |  Kiso, M., et al. 2010. Proc Natl Acad Sci U S A. 107: 882-7. PMID: 20080770
  5. T-705 (favipiravir) inhibition of arenavirus replication in cell culture.  |  Mendenhall, M., et al. 2011. Antimicrob Agents Chemother. 55: 782-7. PMID: 21115797
  6. T-705 (favipiravir) induces lethal mutagenesis in influenza A H1N1 viruses in vitro.  |  Baranovich, T., et al. 2013. J Virol. 87: 3741-51. PMID: 23325689
  7. Mechanism of action of T-705 ribosyl triphosphate against influenza virus RNA polymerase.  |  Sangawa, H., et al. 2013. Antimicrob Agents Chemother. 57: 5202-8. PMID: 23917318
  8. Favipiravir (T-705), a novel viral RNA polymerase inhibitor.  |  Furuta, Y., et al. 2013. Antiviral Res. 100: 446-54. PMID: 24084488
  9. Favipiravir inhibits acetaminophen sulfate formation but minimally affects systemic pharmacokinetics of acetaminophen.  |  Zhao, Y., et al. 2015. Br J Clin Pharmacol. 80: 1076-85. PMID: 25808818
  10. Recent progress on the treatment of Ebola virus disease with Favipiravir and other related strategies.  |  Zhang, T., et al. 2017. Bioorg Med Chem Lett. 27: 2364-2368. PMID: 28462833
  11. Characterization of susceptibility variants of poliovirus grown in the presence of favipiravir.  |  Daikoku, T., et al. 2018. J Microbiol Immunol Infect. 51: 581-586. PMID: 28709841
  12. Comparison of remdesivir and favipiravir - the anti-Covid-19 agents mimicking purine RNA constituents.  |  Al-Ardhi, FM., et al. 2022. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 166: 12-20. PMID: 34782799

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

T-705RTP Sodium Salt, 1 mg

sc-475035
1 mg
$950.00