Synaptotagmin I Antibody (41): sc-136088
- Synaptotagmin I Antibody (41) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 72-223 of Synaptotagmin I of rat origin
- recommended for detection of Synaptotagmin I of mouse, rat and human origin by WBIP; not recommended for IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Synaptotagmin I Antibody (41). This work is in progress.
QUICK LINKS
SEE ALSO...
Synaptotagmin I Antibody (41) is a mouse monoclonal IgG1 antibody that detects Synaptotagmin I in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Synaptotagmin I plays a crucial role in regulating neurotransmitter release at the synapse, acting as a calcium sensor that triggers exocytosis when calcium ions bind. Anti-Synaptotagmin I antibody (41) ensures precise detection of this essential protein, which facilitates communication between neurons through regulated neurotransmitter release. This regulation is essential for various physiological processes, including muscle contraction, hormone secretion, and cognitive functions. Alterations in Synaptotagmin I function have been implicated in several neurological disorders, highlighting Synaptotagmin I′s importance in maintaining synaptic integrity and function. Synaptotagmin I monoclonal antibody (41) serves as an invaluable tool for researchers studying synaptic mechanisms and the pathophysiology of related diseases, providing insights into the intricate processes that govern neurotransmission.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Synaptotagmin I Antibody (41) References:
- Regulation of synaptotagmin I phosphorylation by multiple protein kinases. | Hilfiker, S., et al. 1999. J Neurochem. 73: 921-32. PMID: 10461881
- Synaptotagmin I and IV define distinct populations of neuronal transport vesicles. | Berton, F., et al. 2000. Eur J Neurosci. 12: 1294-302. PMID: 10762358
- The C2B domain of synaptotagmin I is a Ca2+-binding module. | Ubach, J., et al. 2001. Biochemistry. 40: 5854-60. PMID: 11352720
- Synaptotagmin I-DeltaC2B. A novel synaptotagmin isoform with a single C2 domain in the bovine adrenal medulla. | Hewitt, EW., et al. 2002. Biochim Biophys Acta. 1561: 76-90. PMID: 11988182
- Vesicle-associated membrane protein-2/synaptobrevin binding to synaptotagmin I promotes O-glycosylation of synaptotagmin I. | Fukuda, M. 2002. J Biol Chem. 277: 30351-8. PMID: 12048209
- Synaptotagmin I, a Ca2+ sensor for neurotransmitter release. | Koh, TW. and Bellen, HJ. 2003. Trends Neurosci. 26: 413-22. PMID: 12900172
- Synaptotagmin I delays the fast inactivation of Kv1.4 channel through interaction with its N-terminus. | Xie, C., et al. 2014. Mol Brain. 7: 4. PMID: 24423395
- Synaptotagmin I's Intrinsically Disordered Region Interacts with Synaptic Vesicle Lipids and Exerts Allosteric Control over C2A. | Fealey, ME., et al. 2016. Biochemistry. 55: 2914-26. PMID: 27191789
- High affinity interactions of Pb2+ with synaptotagmin I. | Katti, S., et al. 2018. Metallomics. 10: 1211-1222. PMID: 30063057
- Calcium-dependent self-association of synaptotagmin I. | Damer, CK. and Creutz, CE. 1996. J Neurochem. 67: 1661-8. PMID: 8858951
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Synaptotagmin I Antibody (41) | sc-136088 | 50 µg/0.5 ml | $322.00 |