Date published: 2025-12-18

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Sulfamic acid (CAS 5329-14-6)

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Alternate Names:
Amidosulfonic acid
Application:
Sulfamic acid is a compound used in synthesis of sweeteners and therapeutic agents
CAS Number:
5329-14-6
Molecular Weight:
97.09
Molecular Formula:
NH2SO3H
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sulfamic acid, a compound with the chemical formula H3NSO3, holds significant importance in scientific research due to its versatile properties and diverse applications across various disciplines. One of its primary mechanisms of action lies in its role as a strong acid and a versatile reagent in organic synthesis. Sulfamic acid′s acidic nature facilitates protonation reactions, making it valuable in catalyzing esterifications, amidations, and other organic transformations. Moreover, sulfamic acid finds extensive use as a descaling agent in industrial processes and research laboratories. Its ability to dissolve and remove scale deposits, particularly calcium carbonate and calcium sulfate, makes it invaluable in cleaning equipment and removing mineral deposits from surfaces. Additionally, sulfamic acid is utilized in analytical chemistry as a reagent for the determination and quantification of various compounds. Its reaction with nitrous acid serves as a method for the spectrophotometric determination of nitrites, while its ability to react with chloramines enables the removal of excess chlorine from water samples. Furthermore, sulfamic acid has been investigated for its potential in materials science, where it serves as a precursor for the synthesis of sulfamate-based compounds and as a corrosion inhibitor for metal surfaces. Overall, sulfamic acid continues to be a versatile and indispensable tool in scientific investigations, owing to its diverse functionalities and broad utility in research applications spanning organic synthesis, analytical chemistry, industrial processes, and materials science.


Sulfamic acid (CAS 5329-14-6) References

  1. Sulfamates and their therapeutic potential.  |  Winum, JY., et al. 2005. Med Res Rev. 25: 186-228. PMID: 15478125
  2. Removal of nitrite with sulfamic acid for nitrate N and O isotope analysis with the denitrifier method.  |  Granger, J. and Sigman, DM. 2009. Rapid Commun Mass Spectrom. 23: 3753-62. PMID: 19908214
  3. Sulfamic Acid-Catalyzed Lead Perovskite Formation for Solar Cell Fabrication on Glass or Plastic Substrates.  |  Guo, Y., et al. 2016. J Am Chem Soc. 138: 5410-6. PMID: 27054265
  4. Sulfamic acid catalyzed synthesis of new 3,5-[(sub)phenyl]-1H-pyrazole bearing N1-isonicotinoyl: And their pharmacological activity evaluation.  |  Bhirud, JD., et al. 2020. Bioorg Med Chem Lett. 30: 127558. PMID: 32961321
  5. Sulfation of arabinogalactan with sulfamic acid under homogeneous conditions in dimethylsulfoxide medium.  |  Levdansky, AV., et al. 2021. Wood Sci Technol. 55: 1725-1744. PMID: 34690380
  6. Food Xanthan Polysaccharide Sulfation Process with Sulfamic Acid.  |  Kazachenko, AS., et al. 2021. Foods. 10: PMID: 34828852
  7. Catalytic Sulfation of Betulin with Sulfamic Acid: Experiment and DFT Calculation.  |  Kazachenko, AS., et al. 2022. Int J Mol Sci. 23: PMID: 35163526
  8. Sulfamic acid incorporated HKUST-1: a highly active catalyst and efficient adsorbent.  |  Kaid, MM., et al. 2020. RSC Adv. 10: 15586-15597. PMID: 35495473
  9. Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions.  |  Lambat, TL., et al. 2019. RSC Adv. 9: 39735-39742. PMID: 35541403
  10. Sulfation of Birch Wood Microcrystalline Cellulose with Sulfamic Acid Using Ion-Exchange Resins as Catalysts.  |  Kazachenko, AS., et al. 2023. Polymers (Basel). 15: PMID: 36904360

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sulfamic acid, 1 kg

sc-203409
1 kg
$75.00

Sulfamic acid, 3 kg

sc-203409A
3 kg
$185.00

Sulfamic acid, 12 kg

sc-203409B
12 kg
$415.00