Sulfachloropyridazine (CAS 80-32-0)
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Sulfachloropyridazine is a chemical compound that functions as a competitive inhibitor of dihydropteroate synthase, an enzyme involved in the folate synthesis pathway in bacteria. By inhibiting this enzyme, it disrupts the production of tetrahydrofolic acid, and ultimately leads to the inhibition of bacterial growth. Sulfachloropyridazine achieves this by acting as a structural analog of para-aminobenzoic acid (PABA), which is a substrate for dihydropteroate synthase. This structural similarity allows sulfachloropyridazine to bind to the active site of the enzyme, preventing the binding of PABA and subsequent folate synthesis. As a result, the bacteria are unable to produce essential components for DNA and RNA synthesis, ultimately leading to their inability to proliferate. This mechanism of action makes sulfachloropyridazine useful for studying bacterial folate metabolism.
Sulfachloropyridazine (CAS 80-32-0) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulfachloropyridazine, 250 mg | sc-251081 | 250 mg | $87.00 |