Molecular structure of SU 4984, CAS Number: 186610-89-9
SU 4984 (CAS 186610-89-9)
Application:
SU 4984 is an Flg tyrosine kinase inhibitor
CAS Number:
186610-89-9
Purity:
≥98%
Molecular Weight:
333.38
Molecular Formula:
C20H19N3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SU 4984 is an inhibitor of tyrosine kinase activity of fibroblast growth factor receptor 1 (Flg). SU 4984 also inhibits alphaFGF-induced tyrosine phosphorylation of ERK1 and ERK2 and the tyrosine phosphorylation of the PDGF receptor and the insulin receptors. it does not, however, inhibit the kinase activity of the EGF receptor.
SU 4984 (CAS 186610-89-9) References
- The structure-based design of ATP-site directed protein kinase inhibitors. | Toledo, LM., et al. 1999. Curr Med Chem. 6: 775-805. PMID: 10495352
- New approaches to therapy for mastocytosis. A case for treatment with kit kinase inhibitors. | Longley, BJ., et al. 2000. Hematol Oncol Clin North Am. 14: 689-95. PMID: 10909046
- Cdc25A phosphatase suppresses apoptosis induced by serum deprivation. | Fuhrmann, G., et al. 2001. Oncogene. 20: 4542-53. PMID: 11494150
- The tyrosine kinase FRK/RAK participates in cytokine-induced islet cell cytotoxicity. | Welsh, M., et al. 2004. Biochem J. 382: 261-8. PMID: 15186217
- Tumour-derived fibroblast growth factor-2 exerts lymphangiogenic effects through Akt/mTOR/p70S6kinase pathway in rat lymphatic endothelial cells. | Matsuo, M., et al. 2007. Eur J Cancer. 43: 1748-54. PMID: 17570654
- The synthetic inhibitor of fibroblast growth factor receptor PD166866 controls negatively the growth of tumor cells in culture. | Risuleo, G., et al. 2009. J Exp Clin Cancer Res. 28: 151. PMID: 20003343
- The immunopharmacologic potential of Semaxanib and new generation directed therapeutic drugs: Receptor tyrosine kinase regulation with anti-tumorigenensis/angiogenesis properties. | Haddad, JJ. 2012. Saudi Pharm J. 20: 103-23. PMID: 23960782
- Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. | Mohammadi, M., et al. 1997. Science. 276: 955-60. PMID: 9139660
- Fibroblast growth factor receptors regulate the ability for hindlimb regeneration in Xenopus laevis. | D'Jamoos, CA., et al. 1998. Wound Repair Regen. 6: 388-97. PMID: 9824558
Inhibitor of:
Flg, and Tyrosine Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SU 4984, 1 mg | sc-205977 | 1 mg | $95.00 |