Sorbitol Dehydrogenase Antibody (E-11): sc-365760
- Sorbitol Dehydrogenase Antibody (E-11) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 143-171 within an internal region of Sorbitol Dehydrogenase of human origin
- recommended for detection of Sorbitol Dehydrogenase of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Sorbitol Dehydrogenase Antibody (E-11). This work is in progress.
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SEE ALSO...
Sorbitol Dehydrogenase Antibody (E-11) is a mouse monoclonal IgG1 antibody that detects Sorbitol Dehydrogenase (SORD) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SORD, also known as L-iditol 2-dehydrogenase or SORD1, is a 357 amino acid enzyme belonging to the zinc-containing alcohol dehydrogenase family, with highest expression found in the kidney and lens of the eye. Anti-SORD antibody (E-11) recognizes an enzyme that plays a crucial role in the sorbitol pathway, catalyzing the zinc-dependent conversion of polyols like sorbitol and xylitol into corresponding ketoses, a process requiring NAD+ as an oxidizing agent. Proper functioning of SORD is vital for maintaining cellular osmotic balance and preventing sorbitol accumulation, which can lead to diabetic complications such as cataracts and microvascular issues when deficient. SORD monoclonal antibody (E-11) serves as an essential tool for researchers studying metabolic pathways and implications of sorbitol accumulation in various diseases, providing insights into potential therapeutic targets and interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sorbitol Dehydrogenase Antibody (E-11) | sc-365760 | 200 µg/ml | $316.00 | |||
Sorbitol Dehydrogenase (E-11) Neutralizing Peptide | sc-365760 P | 100 µg/0.5 ml | $68.00 |