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Sodium deoxycholate monohydrate (CAS 145224-92-6)

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Alternate Names:
7-Deoxycholic acid sodium salt; Desoxycholic acid sodium salt; 3α,12α-Dihydroxy-5β-cholanic acid sodium salt
Application:
Sodium deoxycholate monohydrate is a powerful solubilizing agent for estrogen synthetase
CAS Number:
145224-92-6
Purity:
≥98%
Molecular Weight:
432.57
Molecular Formula:
C24H39O4•Na•H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sodium deoxycholate monohydrate is a widely used anionic bile-acid detergent in laboratory applications. It serves as useful for disrupting and dissociating protein interactions. This water-soluble ionic detergent is effective in disrupting various types of protein interactions and is employed in protein extraction methods. It finds application as a biological detergent for cell lysis and solubilization of cellular and membrane components. Moreover, Sodium deoxycholate monohydrate is instrumental in the extraction of membrane receptors, plasma membrane proteins, as well as in nuclei isolation. Additionally, it aids in the solubilization of fats and other membrane constituents.


Sodium deoxycholate monohydrate (CAS 145224-92-6) References

  1. Properties of a delipidated, detergent-activated Ca2+--ATPase.  |  Dean, WL. and Tanford, C. 1978. Biochemistry. 17: 1683-90. PMID: 148907
  2. Functionalization impacts the effects of carbon nanotubes on the immune system of rainbow trout, Oncorhynchus mykiss.  |  Klaper, R., et al. 2010. Aquat Toxicol. 100: 211-7. PMID: 20732719
  3. Deoxycholate as an efficient coating agent for hydrophilic silicon nanocrystals.  |  Froner, E., et al. 2011. J Colloid Interface Sci. 358: 86-92. PMID: 21440902
  4. In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation.  |  Bi, YA., et al. 2012. Drug Metab Dispos. 40: 1085-92. PMID: 22381335
  5. Facile synthesis of camptothecin intercalated layered double hydroxide nanohybrids via a coassembly route.  |  Wu, X., et al. 2013. Int J Pharm. 454: 453-61. PMID: 23820133
  6. Piper betle-mediated synthesis, characterization, antibacterial and rat splenocyte cytotoxic effects of copper oxide nanoparticles.  |  Praburaman, L., et al. 2016. Artif Cells Nanomed Biotechnol. 44: 1400-5. PMID: 26148178
  7. Interplay of SpkG kinase and the Slr0151 protein in the phosphorylation of ferredoxin 5 in Synechocystis sp. strain PCC 6803.  |  Angeleri, M., et al. 2018. FEBS Lett. 592: 411-421. PMID: 29331018
  8. Engineering Yarrowia lipolytica to Simultaneously Produce Lipase and Single Cell Protein from Agro-industrial Wastes for Feed.  |  Yan, J., et al. 2018. Sci Rep. 8: 758. PMID: 29335453
  9. Sodium deoxycholate-decorated zein nanoparticles for a stable colloidal drug delivery system.  |  Gagliardi, A., et al. 2018. Int J Nanomedicine. 13: 601-614. PMID: 29430179
  10. TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression.  |  Zhao, Q., et al. 2019. Genome Med. 11: 23. PMID: 31014396
  11. Paclitaxel-loaded sodium deoxycholate-stabilized zein nanoparticles: characterization and in vitro cytotoxicity.  |  Gagliardi, A., et al. 2019. Heliyon. 5: e02422. PMID: 31517130
  12. TYK2 licenses non-canonical inflammasome activation during endotoxemia.  |  Poelzl, A., et al. 2021. Cell Death Differ. 28: 748-763. PMID: 32929218
  13. Effect of amphotericin B on Adriamycin transport in P388 cells.  |  Krishan, A., et al. 1985. Cancer Res. 45: 4097-102. PMID: 4028003
  14. Solubilization of estrogen synthetase from human term placental microsomes using detergents.  |  Bellino, FL. and Osawa, Y. 1978. J Steroid Biochem. 9: 219-28. PMID: 418271

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sodium deoxycholate monohydrate, 5 g

sc-253579
5 g
$162.00

Sodium deoxycholate monohydrate, 500 g

sc-253579A
500 g
$413.00

We need to know if this material is synthetic or animal-derived. In the latter case, please clarify its origin (bovine, porcine, other?). Thanks in advance for your quick reply.

Asked by: JulioARS
Thank you for your question. It's bovine or ovine (usually bovine) but the material is so well processed there is nothing that could be considered animal material left.
Answered by: BlakeJ
Date published: 2023-05-10

Hello, what is the animal source of Sodium Deoxycholate ? Please provide BSE/TSE statements that reflect if this item is bovine.

Asked by: Meghan
BSE/TSE certificates are not provided for all list products and each request will be evaluated on a case by case basis. Please contact technical service if you need any further information.
Answered by: Tech Service
Date published: 2019-06-28
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Rated 5 out of 5 by from Various publications cite the use of SodiumVarious publications cite the use of Sodium deoxycholate monohydrate in the solubilization of estrogen synthetase in human placental microsomes. -SCBT Publication Review
Date published: 2015-05-31
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Sodium deoxycholate monohydrate is rated 5.0 out of 5 by 1.
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