Superoxide Dismutase 2/SOD2 Antibody (18): sc-130345

SOD-2 Antibody (18) is a mouse monoclonal IgG1 antibody that detects SOD-2 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SOD-2 antibody (18) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The superoxide dismutase family, which includes SOD-1, SOD-2, and SOD-3, plays a crucial role in protecting cells from oxidative stress by catalyzing the conversion of reactive oxygen species, such as superoxide anions, into less harmful molecules. SOD-2, specifically, is a homotetrameric manganese enzyme located in the mitochondrial matrix, where SOD-2 is vital for mitigating oxidative damage that can lead to cellular dysfunction and various degenerative diseases, including Alzheimer′s and Parkinson′s diseases. SOD-2 is synthesized in the cytosol and then imported into the mitochondria, highlighting SOD-2′s essential role in mitochondrial health and function. Deficiencies in SOD-2 can result in severe consequences, such as dilated cardiomyopathy and oxidative DNA damage, underscoring the importance of this enzyme in maintaining cellular integrity and preventing disease. Additionally, polymorphisms in the SOD-2 gene have been linked to idiopathic dilated cardiomyopathy in humans, further emphasizing the relevance of SOD-2 in both health and disease.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Superoxide Dismutase 2/SOD2 Antibody (18) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-Superoxide Dismutase 2/SOD2 Antibody (18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Superoxide Dismutase 2/SOD2 Antibody (18) Specifications

Alternate Product Name: SOD2

Product Clone Name: 18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: SOD-2

Epitope Species: human

Product Reactivity/Detection: SOD-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for Superoxide Dismutase 2/SOD2 Antibody (18): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Superoxide Dismutase 2/SOD2 antibody is Superoxide Dismutase 2/SOD2 Antibody (A-2): sc-133134.