Superoxide Dismutase 2/SOD2 Antibody (18): sc-130345

SOD-2 Antibody (18) is a mouse monoclonal IgG1 antibody that detects SOD-2 of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SOD-2 antibody (18) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The superoxide dismutase family, which includes SOD-1, SOD-2, and SOD-3, plays a crucial role in protecting cells from oxidative stress by catalyzing the conversion of reactive oxygen species, such as superoxide anions, into less harmful molecules. SOD-2, specifically, is a homotetrameric manganese enzyme located in the mitochondrial matrix, where SOD-2 is vital for mitigating oxidative damage that can lead to cellular dysfunction and various degenerative diseases, including Alzheimer′s and Parkinson′s diseases. SOD-2 is synthesized in the cytosol and then imported into the mitochondria, highlighting SOD-2′s essential role in mitochondrial health and function. Deficiencies in SOD-2 can result in severe consequences, such as dilated cardiomyopathy and oxidative DNA damage, underscoring the importance of this enzyme in maintaining cellular integrity and preventing disease. Additionally, polymorphisms in the SOD-2 gene have been linked to idiopathic dilated cardiomyopathy in humans, further emphasizing the relevance of SOD-2 in both health and disease.

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Superoxide Dismutase 2/SOD2 Antibody (18) References:

1. Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression.  |  Zelko, IN., et al. 2002. Free Radic Biol Med. 33: 337-49. PMID: 12126755
2. SIRT3-SOD2-mROS-dependent autophagy in cadmium-induced hepatotoxicity and salvage by melatonin.  |  Pi, H., et al. 2015. Autophagy. 11: 1037-51. PMID: 26120888
3. Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway.  |  Chen, ML., et al. 2017. J Am Heart Assoc. 6: PMID: 28871042
4. SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.  |  Gao, J., et al. 2018. Cell Death Differ. 25: 229-240. PMID: 28914882
5. Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway.  |  Gao, JM., et al. 2022. Acta Pharmacol Sin. 43: 2482-2494. PMID: 35292770
6. NAC alleviative ferroptosis in diabetic nephropathy via maintaining mitochondrial redox homeostasis through activating SIRT3-SOD2/Gpx4 pathway.  |  Li, Q., et al. 2022. Free Radic Biol Med. 187: 158-170. PMID: 35660452
7. LCZ696 protects against doxorubicin-induced cardiotoxicity by inhibiting ferroptosis via AKT/SIRT3/SOD2 signaling pathway activation.  |  Liu, X., et al. 2022. Int Immunopharmacol. 113: 109379. PMID: 36330913
8. Analytical Validation of SOD2 Genotyping.  |  Debeljak, M., et al. 2022. Methods Protoc. 6: PMID: 36648953
9. Alleviation of ischemia-reperfusion induced renal injury by chemically modified SOD2 mRNA delivered via lipid nanoparticles.  |  Hou, Y., et al. 2023. Mol Ther Nucleic Acids. 34: 102067. PMID: 38028193
10. TRAF2 inhibits senescence in hepatocellular carcinoma cells via regulating the ROMO1/ NAD+/SIRT3/SOD2 axis.  |  Yao, J., et al. 2024. Free Radic Biol Med. 211: 47-62. PMID: 38043870

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Superoxide Dismutase 2/SOD2 Antibody (18) has 14 citations in a variety of scientific publications.

Primary antibodies like Anti-Superoxide Dismutase 2/SOD2 Antibody (18) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Superoxide Dismutase 2/SOD2 Antibody (18) Specifications

Alternate Product Name: SOD2

Product Clone Name: 18

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: SOD-2

Epitope Species: human

Product Reactivity/Detection: SOD-2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 14 citations in various scientific publications

Available Conjugates/Forms for Superoxide Dismutase 2/SOD2 Antibody (18): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Superoxide Dismutase 2/SOD2 antibody is Superoxide Dismutase 2/SOD2 Antibody (A-2): sc-133134.