SNX9 Antibody (G-5): sc-166863

SNX9 Antibody (G-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects SNX9 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SNX9 Antibody (G-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SNX9 plays a crucial role in cellular membrane trafficking and protein sorting, particularly influencing the processing and trafficking of insulin receptors within the cytosol. SNX9′s ability to interact with specific phospholipids and form protein-protein complexes highlights SNX9′s importance in endosomal sorting and recycling processes. Post-translational modifications, such as phosphorylation, regulate SNX9 by releasing binding partner aldolase, allowing SNX9 to recruit and activate Dynamin II, a key GTPase involved in the late stages of endocytosis. This dynamic regulation underscores SNX9′s role in maintaining cellular homeostasis and potential implications in metabolic disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SNX9 Antibody (G-5) References:

1. Sorting out the cellular functions of sorting nexins.  |  Worby, CA. and Dixon, JE. 2002. Nat Rev Mol Cell Biol. 3: 919-31. PMID: 12461558
2. Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action.  |  MaCaulay, SL., et al. 2003. Biochem J. 376: 123-34. PMID: 12917015
3. Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9.  |  Lundmark, R. and Carlsson, SR. 2004. J Biol Chem. 279: 42694-702. PMID: 15299020
4. Two-step differential expression analysis reveals a new set of genes involved in thyroid oncocytic tumors.  |  Jacques, C., et al. 2005. J Clin Endocrinol Metab. 90: 2314-20. PMID: 15623817
5. Sorting nexins--unifying trends and new perspectives.  |  Carlton, J., et al. 2005. Traffic. 6: 75-82. PMID: 15634208
6. SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis.  |  Soulet, F., et al. 2005. Mol Biol Cell. 16: 2058-67. PMID: 15703209
7. SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1.  |  Yeow-Fong, L., et al. 2005. FEBS Lett. 579: 5040-8. PMID: 16137687
8. Sorting nexins.  |  Carlton, JG. and Cullen, PJ. 2005. Curr Biol. 15: R819-20. PMID: 16243015
9. Dynamin, endocytosis and intracellular signalling (review).  |  McClure, SJ. and Robinson, PJ. 1996. Mol Membr Biol. 13: 189-215. PMID: 9116759

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SNX9 Antibody (G-5) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-SNX9 Antibody (G-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SNX9 Antibody (G-5) Specifications

Alternate Product Name: SNX9

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 391-436

Epitope Target: SNX9

Epitope Species: human

Product Reactivity/Detection: SNX9

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for SNX9 Antibody (G-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin