Molecular structure of SKF 86002, CAS Number: 72873-74-6
SKF 86002 (CAS 72873-74-6)
Alternate Names:
6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole
Application:
SKF 86002 is an inhibitor of p53, Cox, and 5-LO
CAS Number:
72873-74-6
Molecular Weight:
297.4
Molecular Formula:
C16H12FN3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SKF 86002 is a bicyclic imidazole that specifically inhibits p38 MAP kinase, and is also described as a cytokine-suppressant and an anti-inflammatory compound. SKF 86002 has been shown to inhibit Cox (cyclooxygenase) activity and 5-LO (5-lipoxygenase). Osteoblastic cell studies report that SKF 86002 inhibits the production of IL-6. SKF 86002 has been shown to block the activation of TNF-translation and potently inhibit IL-1.
SKF 86002 (CAS 72873-74-6) References
- Activation of p38 MAPK induced peroxynitrite generation in LPS plus IFN-gamma-stimulated rat primary astrocytes via activation of iNOS and NADPH oxidase. | Yoo, BK., et al. 2008. Neurochem Int. 52: 1188-97. PMID: 18289732
- p38 MAPK regulates ischemia-reperfusion-induced recruitment of leukocytes in the colon. | Santén, S., et al. 2009. Surgery. 145: 303-12. PMID: 19231583
- The effect of dual inhibitor, SK&F 86002, on helper T cell functions. | Barton, BE. and James, LC. 1990. Immunopharmacol Immunotoxicol. 12: 105-21. PMID: 2141033
- Inhibition of inflammatory cell infiltration by bicyclic imidazoles, SK&F 86002 and SK&F 104493. | Griswold, DE., et al. 1989. Inflammation. 13: 727-39. PMID: 2559032
- Pharmacokinetics and metabolism of SK&F 86002 in male and female Sprague-Dawley rats. | Newton, JF., et al. 1989. Drug Metab Dispos. 17: 174-9. PMID: 2565207
- SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. | Griswold, DE., et al. 1987. Biochem Pharmacol. 36: 3463-70. PMID: 2823821
- Ovarian effects of SK&F 86002-A2 in the rat: site of action. | Walker, RF., et al. 1988. Toxicol Appl Pharmacol. 94: 276-86. PMID: 3388424
- Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha. | Prichett, W., et al. 1995. J Inflamm. 45: 97-105. PMID: 7583362
- Inhibition of CD44, CD45 and LFA-3 mediated cytokine release from human monocytes by SK&F 86002 and pentoxifylline. | Prabhakar, U., et al. 1993. Int J Immunopharmacol. 15: 205-9. PMID: 7682199
- Bicyclic imidazoles as a novel class of cytokine biosynthesis inhibitors. | Lee, JC., et al. 1993. Ann N Y Acad Sci. 696: 149-70. PMID: 8109825
- SK&F 86002, a dual cytokine and eicosanoid inhibitor, attenuates endotoxin-induced cardiopulmonary dysfunction in the pig. | Triplett, EA., et al. 1996. Shock. 6: 357-64. PMID: 8946652
- Effects of SK&F 86002 on cytokine-stimulated IL6 production in cultured neonatal mouse calvaria and SaOS2 osteoblastic cells: the role of prostaglandins and other mechanisms of action. | Blanque, R., et al. 1997. Drugs Exp Clin Res. 23: 63-70. PMID: 9309381
- p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. | Frasch, SC., et al. 1998. J Biol Chem. 273: 8389-97. PMID: 9525949
Inhibitor of:
5-LO, Cox, IKKα, p38, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SKF 86002, 5 mg | sc-203265 | 5 mg | $153.00 |