SKF 81297 hydrobromide (CAS 71636-61-8)

SKF 81297 hydrobromide is a full D1-like dopamine receptor agonist with diverse applications in scientific research, particularly in neuroscience. It serves as useful for investigating the effects of d-amphetamine and has shown remarkable efficacy in stimulating adenylate cyclase, an enzyme responsible for cAMP synthesis from ATP, exhibiting a 25-fold greater efficacy compared to other compounds. Furthermore, SKF 81297 hydrobromide acts as a selective and potent partial agonist of the human 5-HT2A serotonin receptor, contributing to its significance in the field of neuroscience. This compound′s broad range of applications encompasses in vitro and in vivo studies, allowing researchers to explore its mechanism of action, biological activity, biochemical and physiological effects, pharmacodynamics, and future directions. By binding to the 5-HT2A receptor and activating it to a certain extent, SKF 81297 hydrobromide demonstrates its partial agonist activity. This feature underlies its impact on behavior and cardiovascular function. With its ability to selectively modulate the 5-HT2A receptor, SKF 81297 hydrobromide presents an invaluable resource for understanding the mechanisms of serotonin receptor agonists and antagonists.