Signal peptidase I Antibody (A-12): sc-398136
- Signal peptidase I Antibody (A-12) is a mouse monoclonal IgG1 κ Signal peptidase I antibody provided at 200 µg/ml
- raised against amino acids 1-185 representing full length Signal peptidase I of Streptococcus equi subsp. equi 4047 origin
- Signal peptidase I Antibody (A-12) is recommended for detection of Signal peptidase I of Streptococcus equi subsp. equi 4047 origin by WB, IP, IF and ELISA
- Anti-Signal peptidase I Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Signal peptidase I Antibody (A-12) for WB applications. These reagents are now offered in bundles with Signal peptidase I Antibody (A-12) (see ordering information below).
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Signal peptidase I Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects Signal peptidase I protein of Streptococcus equi subsp. equi 4047 origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Signal peptidase I (A-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Signal peptidase I plays a crucial role in processing pre-proteins, facilitating signal peptide removal during protein maturation, which is essential for proper protein function and cellular localization. This process is particularly important in bacteria, where correct folding and transport of proteins are vital for survival and pathogenicity. In Streptococcus equi subspecies equi, efficient processing of proteins by Signal peptidase I contributes to bacterial ability to establish infection and evade host immune response, making Signal peptidase I a significant target for research into therapeutic interventions against strangles, a highly contagious disease characterized by severe respiratory symptoms and lymphadenitis. Understanding Signal peptidase I function not only sheds light on bacterial pathogenesis but also opens avenues for developing novel antimicrobial strategies.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Signal peptidase I Antibody (A-12) References:
- Getting to grips with strangles: an effective multi-component recombinant vaccine for the protection of horses from Streptococcus equi infection. | Guss, B., et al. 2009. PLoS Pathog. 5: e1000584. PMID: 19763180
- Molecular characterisation of 'strangles' outbreaks in the UK: the use of M-protein typing of Streptococcus equi ssp. equi. | Ivens, PA., et al. 2011. Equine Vet J. 43: 359-64. PMID: 21492215
- Association of Streptococcus equi with equine monocytes. | Mérant, C., et al. 2011. Vet Immunol Immunopathol. 143: 83-6. PMID: 21752476
- Streptococcus equi: a pathogen restricted to one host. | Waller, AS., et al. 2011. J Med Microbiol. 60: 1231-1240. PMID: 21757503
- Streptococcus equi subspecies equi infection (strangles) in horses. | Boyle, A. 2011. Compend Contin Educ Vet. 33: E1-7; quiz E8. PMID: 21870348
- Antiphagocytic function of an IgG glycosyl hydrolase from Streptococcus equi subsp. equi and its use as a vaccine component. | Flock, M., et al. 2012. Infect Immun. 80: 2914-9. PMID: 22615244
- Development of a novel mucosal vaccine against strangles by supercritical enhanced atomization spray-drying of Streptococcus equi extracts and evaluation in a mouse model. | Rodrigues, MA., et al. 2012. Eur J Pharm Biopharm. 82: 392-400. PMID: 22841882
- Detection of Streptococcus equi subspecies equi using a triplex qPCR assay. | Webb, K., et al. 2013. Vet J. 195: 300-4. PMID: 22884566
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Signal peptidase I Antibody (A-12) | sc-398136 | 200 µg/ml | $316.00 | |||
Signal peptidase I Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-530701 | 200 µg Ab; 10 µg BP | $354.00 | |||
Signal peptidase I Antibody (A-12): m-IgGκ BP-HRP Bundle | sc-524228 | 200 µg Ab, 40 µg BP | $354.00 | |||
Signal peptidase I Antibody (A-12): m-IgG1 BP-HRP Bundle | sc-544208 | 200 µg Ab; 20 µg BP | $354.00 | |||
Signal peptidase I Antibody (A-12) AC | sc-398136 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Signal peptidase I Antibody (A-12) HRP | sc-398136 HRP | 200 µg/ml | $316.00 | |||
Signal peptidase I Antibody (A-12) FITC | sc-398136 FITC | 200 µg/ml | $330.00 | |||
Signal peptidase I Antibody (A-12) PE | sc-398136 PE | 200 µg/ml | $343.00 | |||
Signal peptidase I Antibody (A-12) Alexa Fluor® 488 | sc-398136 AF488 | 200 µg/ml | $357.00 | |||
Signal peptidase I Antibody (A-12) Alexa Fluor® 546 | sc-398136 AF546 | 200 µg/ml | $357.00 | |||
Signal peptidase I Antibody (A-12) Alexa Fluor® 594 | sc-398136 AF594 | 200 µg/ml | $357.00 | |||
Signal peptidase I Antibody (A-12) Alexa Fluor® 647 | sc-398136 AF647 | 200 µg/ml | $357.00 | |||
Signal peptidase I Antibody (A-12) Alexa Fluor® 680 | sc-398136 AF680 | 200 µg/ml | $357.00 | |||
Signal peptidase I Antibody (A-12) Alexa Fluor® 790 | sc-398136 AF790 | 200 µg/ml | $357.00 |