Molecular structure of SID 26681509, CAS Number: 958772-66-2
SID 26681509 (CAS 958772-66-2)
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Alternate Names:
N-[(1,1-Dimethylethoxy)carbonyl]-L-tryptophan-2-[[[2-[(2-ethylphenyl)amino]-2-oxoethyl]thio]carbonyl]hydrazide
Application:
SID 26681509 is a reversible and potent human cathepsin L inhibitor
CAS Number:
958772-66-2
Molecular Weight:
539.65
Molecular Formula:
C27H33N5O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SID 26681509 is a compound of interest for biochemical research due to its inhibitory action on human cathepsin L. As a potent inhibitor, this chemical is pivotal in studies of protease activity, particularly in understanding the mechanisms of protein degradation. Its reversible binding capability allows researchers to investigate the dynamic nature of enzyme-substrate interactions. Moreover, this compound is utilized in the exploration of signaling pathways where cathepsin L plays a role, contributing to the elucidation of cellular processes such as apoptosis and autophagy. This compound is also a valuable asset in the field of protein engineering, where modifying protease activity can lead to the development of new biomolecules with novel properties.
SID 26681509 (CAS 958772-66-2) References
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- Vitamin D inhibits human immunodeficiency virus type 1 and Mycobacterium tuberculosis infection in macrophages through the induction of autophagy. | Campbell, GR. and Spector, SA. 2012. PLoS Pathog. 8: e1002689. PMID: 22589721
- Autophagy induction by histone deacetylase inhibitors inhibits HIV type 1. | Campbell, GR., et al. 2015. J Biol Chem. 290: 5028-5040. PMID: 25540204
- The HIV Protease Inhibitor Saquinavir Inhibits HMGB1-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88. | Pribis, JP., et al. 2015. Mol Med. 21: 749-757. PMID: 26349060
- Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening. | Calcaterra, NE., et al. 2016. Sci Rep. 6: 19976. PMID: 26879421
- Bone morphogenetic protein 1 cleaves the linker region between ligand-binding repeats 4 and 5 of the LDL receptor and makes the LDL receptor non-functional. | Strøm, TB., et al. 2020. Hum Mol Genet. 29: 1229-1238. PMID: 31600776
- In Silico Identification of Potential Natural Product Inhibitors of Human Proteases Key to SARS-CoV-2 Infection. | Vivek-Ananth, RP., et al. 2020. Molecules. 25: PMID: 32842606
- The role of cysteine peptidases in coronavirus cell entry and replication: The therapeutic potential of cathepsin inhibitors. | Pišlar, A., et al. 2020. PLoS Pathog. 16: e1009013. PMID: 33137165
- Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development. | Zhao, MM., et al. 2021. Signal Transduct Target Ther. 6: 134. PMID: 33774649
- Exploring SARS-CoV-2 Spikes Glycoproteins for Designing Potential Antiviral Targets. | Kamel, NA., et al. 2021. Viral Immunol. 34: 510-521. PMID: 34018828
- Rational design of thioamide peptides as selective inhibitors of cysteine protease cathepsin L. | Phan, HAT., et al. 2021. Chem Sci. 12: 10825-10835. PMID: 35355937
- SARS-CoV-2 ORF7a potently inhibits the antiviral effect of the host factor SERINC5. | Timilsina, U., et al. 2022. Nat Commun. 13: 2935. PMID: 35618710
- Exploring the oncogenic roles of LINC00857 in pan-cancer. | Ren, X., et al. 2022. Front Pharmacol. 13: 996686. PMID: 36160408
Inhibitor of:
Cathepsin, and cathepsin L.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SID 26681509, 10 mg | sc-361358 | 10 mg | $421.00 | |||
| US: Only available in the US | ||||||
SID 26681509, 50 mg | sc-361358A | 50 mg | $1569.00 | |||
| US: Only available in the US | ||||||