Dieser polyklonale Antikörper wird nicht mehr hergestellt. Wir empfehlen Ihnen unseren SIAH-1/2 (8G7H12) monoklonalen Antikörper (Beispielsdaten werden angezeigt).
SIAH-1 Antikörper (N-15): sc-5505
- SIAH-1 Antikörper N-15 ist ein polyklonales IgG aus der Ziege in einer Menge von 100 µg/ml
- das Epitop liegt am N-terminus von SIAH-1 aus der Spezies human
- Nicht länger erhältlicher polyklonaler Antikörper
SIAH, the human homolog of the Drosophila seven in absentia (sina) gene, is a tumor suppressor protein that is expressed in intestinal epithelium and activated during apoptosis. Human SIAH proteins are produced as two distinct gene products, SIAH-1, and the slightly larger protein SIAH-2, which share a highly conserved C-terminal sequence and differ in their N-terminal regions. SIAH-1 contains an N-terminal RING-finger domain, which is required for proteolysis, and a cystein-rich C-terminal domain, which regulates oligomerization and SIAH binding to target proteins. As a tumor suppressor, SIAH-1 binds DCC (deleted in colorectal cancer) and regulates DCC degradation via the ubiquitin-proteasome pathway. SIAH-1 also binds a Bcl-2 related protein, Bag-1, thereby inhibiting cell growth. The majority of SIAH-1 is localized to the nucleus, however a small percentage is detected in the cytoplasm. This nuclear localization suggests that SIAH proteins may interact with other nuclear matrix proteins and DNA.
Bestellinformation
SIAH-1/2 (8G7H12): sc-81785 [ Empfohlener monoklonaler Ersatz für SIAH-1 (N-15) ]
| Produkt | Katalog # | EINHEIT | Preis | ANZAHL | Favoriten | |
SIAH-1/2 Antikörper (8G7H12) | sc-81785 | 200 µg/ml | $322.00 | |||
SIAH-1/2 Antikörper (8G7H12) AC | sc-81785 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SIAH-1/2 Antikörper (8G7H12) HRP | sc-81785 HRP | 200 µg/ml | $322.00 | |||
SIAH-1/2 Antikörper (8G7H12) FITC | sc-81785 FITC | 200 µg/ml | $336.00 | |||
SIAH-1/2 Antikörper (8G7H12) PE | sc-81785 PE | 200 µg/ml | $349.00 | |||
SIAH-1/2 Antikörper (8G7H12) Alexa Fluor® 488 | sc-81785 AF488 | 200 µg/ml | $364.00 | |||
SIAH-1/2 Antikörper (8G7H12) Alexa Fluor® 546 | sc-81785 AF546 | 200 µg/ml | $364.00 | |||
SIAH-1/2 Antikörper (8G7H12) Alexa Fluor® 594 | sc-81785 AF594 | 200 µg/ml | $364.00 | |||
SIAH-1/2 Antikörper (8G7H12) Alexa Fluor® 647 | sc-81785 AF647 | 200 µg/ml | $364.00 | |||
SIAH-1/2 Antikörper (8G7H12) Alexa Fluor® 680 | sc-81785 AF680 | 200 µg/ml | $364.00 | |||
SIAH-1/2 Antikörper (8G7H12) Alexa Fluor® 790 | sc-81785 AF790 | 200 µg/ml | $364.00 |