SGK2 Antibody (3Q-2): sc-100355

SGK2 Antibody (3Q-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects SGK2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-SGK2 antibody (3Q-2) is available as a non-conjugated format. The serum- and glucocorticoid-regulated kinases (SGKs), which include SGK1, SGK2, and SGK3, are integral members of the serine/threonine protein kinase family, playing crucial roles in cellular signaling pathways. SGK2 is primarily expressed in the liver, kidney, and pancreas, where SGK2 is involved in regulating various physiological processes. SGK2 activates specific ion channels, such as epithelial sodium channels (ENaC), which are vital for maintaining sodium balance and fluid homeostasis in the body. This regulation is particularly important in the context of renal function and blood pressure control, as SGK2 influences sodium reabsorption in the kidneys. Additionally, SGK2 is a downstream target of phosphoinositide 3-kinase (PI3K) signaling, linking growth factor signaling to the modulation of ion transport and cell survival. The structural similarity of SGK2 to the PKB/Akt family, despite the absence of a Pleckstrin homology domain, highlights SGK2′s unique regulatory mechanisms and potential as a therapeutic target in conditions related to ion transport dysregulation.

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SGK2 Antibody (3Q-2) References:

1. Serum and glucocorticoid-inducible kinase (SGK) is a target of the PI 3-kinase-stimulated signaling pathway.  |  Park, J., et al. 1999. EMBO J. 18: 3024-33. PMID: 10357815
2. Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms.  |  Lang, F. and Cohen, P. 2001. Sci STKE. 2001: re17. PMID: 11707620
3. K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK.  |  Gamper, N., et al. 2002. Pflugers Arch. 445: 60-6. PMID: 12397388
4. The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC.  |  Friedrich, B., et al. 2003. Pflugers Arch. 445: 693-6. PMID: 12632189
5. Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3.  |  Tessier, M. and Woodgett, JR. 2006. J Biol Chem. 281: 23978-89. PMID: 16790420
6. Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase.  |  Kobayashi, T., et al. 1999. Biochem J. 344 Pt 1: 189-97. PMID: 10548550

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SGK2 Antibody (3Q-2) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-SGK2 Antibody (3Q-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SGK2 Antibody (3Q-2) Specifications

Alternate Product Name: SGK2

Product Clone Name: 3Q-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 293-367

Epitope Target: SGK2

Epitope Species: human

Product Reactivity/Detection: SGK2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for SGK2 Antibody (3Q-2): N/A