SERGEF Antibody (2261C3a): sc-81078

SERGEF Antibody (2261C3a) is a mouse monoclonal IgG1 antibody that detects SERGEF in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). SERGEF, also known as DelGEF, plays a crucial role as a guanine nucleotide exchange factor involved in secretion pathways, which are essential for various cellular processes, including the release of hormones and neurotransmitters. SERGEF interacts with Sec5, a key component required for secretion, in a magnesium-dependent manner and is activated by the presence of deoxycytidine triphosphate or guanosine triphosphate, highlighting its importance in regulating cellular signaling and secretion. SERGEF is predominantly localized in the nucleus and cytoplasm, with significant expression levels found in the brain, placenta, and skeletal muscle, indicating its vital functions across different tissues. SERGEF consists of 458 amino acids and undergoes phosphorylation by Atm or ATR in response to DNA damage, which may influence its activity and interactions. Additionally, SERGEF has two isoforms resulting from alternative splicing, further diversifying its functional roles within the cell. Anti-SERGEF antibody (2261C3a) is an invaluable tool for researchers studying the mechanisms of secretion and cellular signaling in human biology.

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SERGEF Antibody (2261C3a) References:

1. DelGEF, an RCC1-related protein encoded by a gene on chromosome 11p14 critical for two forms of hereditary deafness.  |  Uhlmann, J., et al. 1999. FEBS Lett. 460: 153-60. PMID: 10571079
2. DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion.  |  Sjölinder, M., et al. 2002. FEBS Lett. 532: 211-5. PMID: 12459492
3. Characterisation of an evolutionary conserved protein interacting with the putative guanine nucleotide exchange factor DelGEF and modulating secretion.  |  Sjölinder, M., et al. 2004. Exp Cell Res. 294: 68-76. PMID: 14980502
4. Demographic, psychosocial, and genetic risk associated with smokeless tobacco use among Mexican heritage youth.  |  Wilkinson, AV., et al. 2015. BMC Med Genet. 16: 43. PMID: 26111525
5. A robust biomarker of differential correlations improves the diagnosis of cytologically indeterminate thyroid cancers.  |  Gomez-Rueda, H., et al. 2016. Int J Mol Med. 37: 1355-62. PMID: 27035928
6. GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment.  |  Song, KH., et al. 2016. Nat Commun. 7: 13796. PMID: 27982029
7. Admixture Mapping of Subclinical Atherosclerosis and Subsequent Clinical Events Among African Americans in 2 Large Cohort Studies.  |  Shendre, A., et al. 2017. Circ Cardiovasc Genet. 10: PMID: 28408707
8. Genome-wide admixture and association study of subclinical atherosclerosis in the Women's Interagency HIV Study (WIHS).  |  Shendre, A., et al. 2017. PLoS One. 12: e0188725. PMID: 29206233
9. Aberrantly Methylated-Differentially Expressed Genes Identify Novel Atherosclerosis Risk Subtypes.  |  Xue, Y., et al. 2020. Front Genet. 11: 569572. PMID: 33381146
10. Elucidation of population stratifying markers and selective sweeps in crossbred Landlly pig population using genome-wide SNP data.  |  Saini, T., et al. 2024. Mamm Genome. 35: 170-185. PMID: 38485788

The preferred SERGEF antibody is SERGEF Antibody (H-12): sc-515188.