Secologanin (CAS 19351-63-4)
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Secologanin is a pivotal terpenoid glycoside that plays a critical role in the biosynthesis of indole alkaloids, a diverse class of compounds widely studied for their intricate structures and biological activities. Secologanin is integral to the metabolic pathways that lead to the formation of various molecules, such as vincristine and vinblastine, which are noted for their roles in research related to cell cycle dynamics and cellular communication. The compound′s involvement in the synthesis of these molecules provides a foundational understanding of plant secondary metabolism and the ecological interactions mediated by these chemical entities. By acting as a key precursor in the enzymatic processes that generate complex alkaloids, secologanin not only contributes to the diversification of natural products but also facilitates the exploration of their synthesis, offering insights into the development of bio-inspired synthesis strategies.
Secologanin (CAS 19351-63-4) References
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- Biotransformation of tryptamine and secologanin into plant terpenoid indole alkaloids by transgenic yeast. | Geerlings, A., et al. 2001. Appl Microbiol Biotechnol. 56: 420-4. PMID: 11549013
- Investigation of Pictet-Spengler type reactions of secologanin with histamine and its benzyl derivative. | Beke, G., et al. 2002. J Nat Prod. 65: 649-55. PMID: 12027735
- Comparison of extraction methods for secologanin and the quantitative analysis of secologanin from Symphoricarpos albus using 1H-NMR. | Kim, HK., et al. 2004. Phytochem Anal. 15: 257-61. PMID: 15311846
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- A 7-deoxyloganetic acid glucosyltransferase contributes a key step in secologanin biosynthesis in Madagascar periwinkle. | Asada, K., et al. 2013. Plant Cell. 25: 4123-34. PMID: 24104568
- Inter-organ transport of secologanin allows assembly of monoterpenoid indole alkaloids in a Catharanthus roseus mutant. | Kidd, T., et al. 2019. Phytochemistry. 159: 119-126. PMID: 30611871
- Tabernabovines A-C: Three Monoterpenoid Indole Alkaloids from the Leaves of Tabernaemontana bovina. | Yu, Y., et al. 2019. Org Lett. 21: 5938-5942. PMID: 31294995
- Privileged Biorenewable Secologanin-Based Diversity-Oriented Synthesis for Pseudo-Natural Alkaloids: Uncovering Novel Neuroprotective and Antimalarial Frameworks. | Zhu, H., et al. 2021. ChemSusChem. 14: 5320-5327. PMID: 34636473
- Single mutations toggle the substrate selectivity of multifunctional Camptotheca secologanic acid synthases. | Miller, JC. and Schuler, MA. 2022. J Biol Chem. 298: 102237. PMID: 35809640
- The iridoid glucoside secologanin is derived from the novel triose phosphate/pyruvate pathway in a Catharanthus roseus cell culture. | Contin, A., et al. 1998. FEBS Lett. 434: 413-6. PMID: 9742965
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Secologanin, 5 mg | sc-229289 | 5 mg | $132.00 |