Molecular structure of SDZ NKT 343, CAS Number: 180046-99-5
SDZ NKT 343 (CAS 180046-99-5)
Alternate Names:
1-[[(2-Nitrophenyl)amino]carbonyl]-L-prolyl-N-methyl-3-(2-naphthalenyl)-N-(phenylmethyl)-L-alaninamide
Application:
SDZ NKT 343 is a human tachykinin NK1 antagonist receptor
CAS Number:
180046-99-5
Molecular Weight:
579.65
Molecular Formula:
C33H33N5O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SDZ NKT 343 is a highly selective human tachykinin NK1 antagonist receptor(IC50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK2 and NK3 receptors. SDZ NKT 343 potently antagonizes SP-induced Ca2+ efflux in vitro.
SDZ NKT 343 (CAS 180046-99-5) References
Walpole et al (1998) Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist. Br.J.Pharmacol. 124 83. Walpole et al (1998) 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models. J.Med.Chem. 41 3159. Campbell et al (1998) Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig. Neuroscience. 87 527.Inhibitor of:
NK-1R.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SDZ NKT 343, 10 mg | sc-204274 | 10 mg | $255.00 |