SDZ NKT 343 CAS: 180046-99-5
MF: C33H33N5O5
MW: 579.65
A human tachykinin NK1 antagonist receptor.

SDZ NKT 343 (CAS 180046-99-5)

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Application: A human tachykinin NK1 antagonist receptor
CAS Number: 180046-99-5
Molecular Weight: 579.65
Molecular Formula: C33H33N5O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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SDZ NKT 343 is a highly selective human tachykinin NK1 antagonist receptor(IC50 values are 0.62 and 451 nM for human and rat receptors respectively) that displays > 130-fold selectivity over human NK2 and NK3 receptors. SDZ NKT 343 potently antagonizes SP-induced Ca2+ efflux in vitro.


References

Walpole et al (1998) Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist. Br.J.Pharmacol. 124 83. Walpole et al (1998) 2-Nitrophenylcarbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide (SDZ NKT 343), a potent human NK1 tachykinin receptor antagonist with good oral analgesic activity in chronic pain models. J.Med.Chem. 41 3159. Campbell et al (1998) Selective neurokinin-1 receptor antagonists are anti-hyperalgesic in a model of neuropathic pain in the guinea-pig. Neuroscience. 87 527.

Physical State :
Solid
Solubility :
Soluble to 100 mM in DMSO and to 100 mM in Ethanol
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9851211
SMILES :
CN(CC1=CC=CC=C1)C(=O)[[email protected]](CC2=CC3=CC=CC=C3C=C2)NC(=O)[[email protected]@H]4CCCN4C(=O)NC5=CC=CC=C5[N+](=O)[O-]

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Certificate of Analysis

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