Scrib Antibody (D-8): sc-55532
- Scrib Antibody (D-8) is a mouse monoclonal IgM κ, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1331-1630 deletion 1444-1504 (deletion 1444-1504) mapping at the C-terminus of Scrib of human origin
- recommended for detection of Scrib of human origin by WB, IP, IF, IHC(P) and ELISA
- See Scrib (C-6): sc-55543 for Scrib antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Scrib Antibody (D-8). This work is in progress.
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SEE ALSO...
Scrib Antibody (D-8) is a mouse monoclonal IgM antibody that detects Scrib in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Scrib, a crucial member of the PDZ domain-containing protein family, plays a significant role in maintaining epithelial integrity and regulating cell polarity, which is vital for proper tissue architecture and function. Located at the tight junctions of epithelial cells, Scrib interacts with other proteins to facilitate the correct localization of adherens junctions, thereby influencing cell adhesion and signaling pathways. Scrib′s structure, characterized by multiple PDZ domains, allows binding to specific sequences at the C-terminus of target proteins, which is essential for function in protein trafficking and cellular organization. Mutations in Scrib can lead to aberrant cell shapes and loss of monolayer organization, highlighting Scrib′s importance in morphogenesis and cell differentiation. Anti-Scrib antibody (D-8) serves as an invaluable tool for researchers studying the dynamics of cell polarity and molecular mechanisms underlying epithelial integrity in human tissues.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Scrib Antibody (D-8) | sc-55532 | 200 µg/ml | $322.00 |