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SCP-3 Antibody (G-3): sc-74568

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Datasheets
  • SCP-3 Antibody (G-3) is a mouse monoclonal IgG2b κ, cited in 7 publications, provided at 200 µg/ml
  • raised against amino acids 1-254 representing full length SCP-3 of mouse origin
  • recommended for detection of SCP-3 of mouse and rat origin by WB, IP, IF and ELISA
  • See SCP-3 (D-1): sc-74569 for SCP-3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SCP-3 Antibody (G-3). This work is in progress.

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SCP-3 Antibody (G-3) is a mouse monoclonal IgG2b light chain antibody that detects SCP-3 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SCP-3 plays a crucial role in meiosis, specifically as a component of the synaptonemal complex, which is essential for chromosome pairing and recombination during meiotic prophase. SCP-3 (G-3) antibody localizes primarily in the nucleus of testicular meiotic prophase cells and primordial germ cells, where anti-SCP-3 antibody (G-3) facilitates the proper alignment and segregation of homologous chromosomes. SCP-3 maintains chromosomal integrity during meiosis, acting as a sister chromatid arm cohesin during mammalian meiosis I, ensuring accurate chromosome pairing and recombination. Notably, SCP-3 features a C-terminal coiled-coil domain that promotes homotypic interactions, which are critical for the structural stability of the synaptonemal complex. Expression of SCP-3 begins in leptotene-stage spermatocytes and is lost in late meiotic cells, highlighting a transient yet essential role in the meiotic process. SCP-3 monoclonal antibody (G-3) serves as an invaluable tool for researchers studying meiosis and chromosomal dynamics.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

SCP-3 Antibody (G-3) References:

  1. The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility.  |  Yuan, L., et al. 2000. Mol Cell. 5: 73-83. PMID: 10678170
  2. The meiotic specific synaptonemal complex protein SCP3 is expressed by female and male primordial germ cells of the mouse embryo.  |  Di Carlo, AD., et al. 2000. Int J Dev Biol. 44: 241-4. PMID: 10794082
  3. A rare synaptonemal complex protein 3 gene variant in unexplained female infertility.  |  Nishiyama, S., et al. 2011. Mol Hum Reprod. 17: 266-71. PMID: 21159741
  4. Synaptonemal complex protein 3 as a novel prognostic marker in early stage non-small cell lung cancer.  |  Chung, JY., et al. 2013. Hum Pathol. 44: 472-9. PMID: 23069255
  5. Analysis of SYCP3 encoding synaptonemal complex protein 3 in human aneuploidies.  |  Roos, A., et al. 2013. Arch Gynecol Obstet. 288: 1153-8. PMID: 23677416
  6. Synaptonemal complex protein 3 is a prognostic marker in cervical cancer.  |  Cho, H., et al. 2014. PLoS One. 9: e98712. PMID: 24905095
  7. Synaptonemal complex protein 3 is associated with lymphangiogenesis in non-small cell lung cancer patients with lymph node metastasis.  |  Kitano, H., et al. 2017. J Transl Med. 15: 138. PMID: 28623914
  8. Interaction between SCP3 and JAB1 Confers Cancer Therapeutic Resistance and Stem-like Properties through EGF Expression.  |  Oh, SJ., et al. 2021. Int J Mol Sci. 22: PMID: 34445562
  9. The synaptonemal complex protein SCP3 can form multistranded, cross-striated fibers in vivo.  |  Yuan, L., et al. 1998. J Cell Biol. 142: 331-9. PMID: 9679134
  10. Localization of SCP2 and SCP3 protein molecules within synaptonemal complexes of the rat.  |  Schalk, JA., et al. 1998. Chromosoma. 107: 540-8. PMID: 9933407

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

SCP-3 Antibody (G-3)

sc-74568
200 µg/ml
$316.00

I am using the LiCor/Odyssey system. Which secondary antibody do you recommend using with SCP-3 (G-3): sc-74568?

Asked by: Dr Ninau Qelp
We recommend using one of our our exclusive Mouse IgG Binding Proteins conjugated to CFL 680 or CFL 790. They are suitable for use with Near-Infrared (NIR) detection systems, such as LI-COR/Odyssey and other comparable systems. A complete list of available binding proteins is available on our website here: https://www.scbt.com/scbt/browse/support-products-mouse-igg-binding-proteins/_/N-ecrety
Answered by: Technical Support
Date published: 2017-02-27
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Rated 5 out of 5 by from Positive results in western blot analysis of SCPPositive results in western blot analysis of SCP-3 expression in mouse testis and rat testis tissue extracts. -SCBT QC
Date published: 2015-04-04
Rated 5 out of 5 by from This antibody was used in a publication forThis antibody was used in a publication for IF on mice spermatocytes - SCBT Publication Review
Date published: 2015-01-22
Rated 5 out of 5 by from 1:200 dilution used for IF with murine spermatocytes. - SCBT Publication Review
Date published: 2014-08-17
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SCP-3 Antibody (G-3) is rated 5.0 out of 5 by 3.
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