Molecular structure of SCH 39166 hydrobromide, CAS Number: 1227675-51-5
SCH 39166 hydrobromide (CAS 1227675-51-5)
Alternate Names:
Ecopipam hydrobromide
Application:
SCH 39166 hydrobromide is a high affinity D1DR/D5DR antagonist
CAS Number:
1227675-51-5
Purity:
≥98%
Molecular Weight:
394.73
Molecular Formula:
C19H20ClNO•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SCH 39166 hydrobromide is a high affinity D1DR/D5DR antagonist displays Ki values of 1.2, 2, 980, 5520, 80 and 731 nM for binding to D1DR, D5DR, D2DR, D4DR, 5-HT receptor and alpha2a-AR (alpha2a receptor), respectively. It acts as a selective antagonist at the dopamine D1 receptor subtype. By blocking the binding of dopamine to D1 receptors, SCH 39166 hydrobromide inhibits the transmission of dopaminergic signals in the brain.
SCH 39166 hydrobromide (CAS 1227675-51-5) References
- Interactions between adenosine and dopamine receptor antagonists with different selectivity profiles: Effects on locomotor activity. | Collins, LE., et al. 2010. Behav Brain Res. 211: 148-55. PMID: 20211657
- Inhibition of 50-kHz ultrasonic vocalizations by dopamine receptor subtype-selective agonists and antagonists in adult rats. | Scardochio, T. and Clarke, PB. 2013. Psychopharmacology (Berl). 226: 589-600. PMID: 23192317
- Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate action. | Zhang, CL., et al. 2012. PLoS One. 7: e51910. PMID: 23284812
- Dopamine signaling in the amygdala, increased by food ingestion and GLP-1, regulates feeding behavior. | Anderberg, RH., et al. 2014. Physiol Behav. 136: 135-44. PMID: 24560840
- The dopamine D1 receptor agonist SKF-82958 effectively increases eye blinking count in common marmosets. | Kotani, M., et al. 2016. Behav Brain Res. 300: 25-30. PMID: 26675887
- Electrical and Ca(2+) signaling in dendritic spines of substantia nigra dopaminergic neurons. | Hage, TA., et al. 2016. Elife. 5: PMID: 27163179
- Optimization and pharmacological characterization of receptor-mediated Gi/o activation in postmortem human prefrontal cortex. | Odagaki, Y., et al. 2019. Basic Clin Pharmacol Toxicol. 124: 649-659. PMID: 30507034
- The contribution of medium spiny neuron subtypes in the nucleus accumbens core to compulsive-like ethanol drinking. | Sneddon, EA., et al. 2021. Neuropharmacology. 187: 108497. PMID: 33582151
- A novel phosphodiesterase 1 inhibitor reverses L-dopa-induced dyskinesia, but not motivation deficits, in monkeys. | Enomoto, T., et al. 2021. Pharmacol Biochem Behav. 205: 173183. PMID: 33774006
- Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice. | Kesner, AJ., et al. 2021. Nat Commun. 12: 2811. PMID: 33990558
- Effect of dopamine receptor-related compounds on naïve common marmosets for auditory steady-state response. | Iwamura, Y., et al. 2022. J Neurophysiol. 128: 229-238. PMID: 35583977
- Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development. | Gerhards, J., et al. 2023. J Am Soc Nephrol. 34: 590-606. PMID: 36810260
Inhibitor of:
D1DR, D5DR, and DARPP-32.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCH 39166 hydrobromide, 10 mg | sc-204270 | 10 mg | $234.00 | |||
| US: Only available in the US | ||||||
SCH 39166 hydrobromide, 50 mg | sc-204270A | 50 mg | $941.00 | |||
| US: Only available in the US | ||||||