Molecular structure of SCH-202676 hydrobromide, CAS Number: 70375-43-8
SCH-202676 hydrobromide (CAS 70375-43-8)
Alternate Names:
N-(2,3-diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene)methanamine hydrobromide
Application:
SCH-202676 hydrobromide is a modulator that inhibits binding to G protein-coupled receptors
CAS Number:
70375-43-8
Purity:
≥99%
Molecular Weight:
348.3
Molecular Formula:
C15H13N3S•HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SCH-202676 hydrobromide is a G protein-coupled receptor allosteric modulator that may act to inhibit agonist and antagonist binding to a wide range of G protein-coupled receptors that are structurally unrelated. SCH-202676 hydrobromide has displayed divergent effects on purine receptors. It is reported to inhibit radioligand binding to human Adenosine A1-R, A2A-R, and A3-R and thus affects dissociation kinetics.
SCH-202676 hydrobromide (CAS 70375-43-8) References
- SCH-202676: An allosteric modulator of both agonist and antagonist binding to G protein-coupled receptors. | Fawzi, AB., et al. 2001. Mol Pharmacol. 59: 30-7. PMID: 11125021
- Investigation of the interaction of a putative allosteric modulator, N-(2,3-diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) methanamine hydrobromide (SCH-202676), with M1 muscarinic acetylcholine receptors. | Lanzafame, A. and Christopoulos, A. 2004. J Pharmacol Exp Ther. 308: 830-7. PMID: 14617684
- Synthesis and biological evaluation of 2,3,5-substituted [1,2,4]thiadiazoles as allosteric modulators of adenosine receptors. | van den Nieuwendijk, AM., et al. 2004. J Med Chem. 47: 663-72. PMID: 14736246
- Effects of the allosteric modulator SCH-202676 on adenosine and P2Y receptors. | Gao, ZG., et al. 2004. Life Sci. 74: 3173-80. PMID: 15081581
- Allosteric modulators affect the internalization of human adenosine A1 receptors. | Klaasse, EC., et al. 2005. Eur J Pharmacol. 522: 1-8. PMID: 16214128
- The 'allosteric modulator' SCH-202676 disrupts G protein-coupled receptor function via sulphydryl-sensitive mechanisms. | Lewandowicz, AM., et al. 2006. Br J Pharmacol. 147: 422-9. PMID: 16402041
- Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization. | Roberts, S., et al. 2007. J Bone Miner Res. 22: 617-27. PMID: 17227223
- Novel consequences of voltage-dependence to G-protein-coupled P2Y1 receptors. | Gurung, IS., et al. 2008. Br J Pharmacol. 154: 882-9. PMID: 18414379
- Effect of purinergic receptor activation on Na+-K+ pump activity, excitability, and function in depolarized skeletal muscle. | Broch-Lips, M., et al. 2010. Am J Physiol Cell Physiol. 298: C1438-44. PMID: 20457838
- The effect of adenosine on pro-inflammatory cytokine production by porcine T cells. | Ondrackova, P., et al. 2012. Vet Immunol Immunopathol. 145: 332-9. PMID: 22222199
- Peptide Lv augments L-type voltage-gated calcium channels through vascular endothelial growth factor receptor 2 (VEGFR2) signaling. | Shi, L., et al. 2015. Biochim Biophys Acta. 1853: 1154-64. PMID: 25698653
- Arachidonic acid triggers [Ca2+]i increases in rat round spermatids by a likely GPR activation, ERK signalling and ER/acidic compartments Ca2+ release. | Paillamanque, J., et al. 2017. PLoS One. 12: e0172128. PMID: 28192519
- Increased Neuronal Depolarization Evoked by Autoantibodies in Diabetic Obstructive Sleep Apnea: Role for Inflammatory Protease(s) in Generation of Neurotoxic Immunoglobulin Fragment. | Zimering, MB. and Pan, Z. 2017. J Endocrinol Diabetes. 4: PMID: 29805992
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SCH-202676 hydrobromide, 10 mg | sc-200835 | 10 mg | $110.00 | |||
SCH-202676 hydrobromide, 50 mg | sc-200835A | 50 mg | $434.00 |