SCAND2 Antibody (D-19): sc-100975

SCAND2 Antibody (D-19) is a mouse monoclonal IgG2a kappa light chain antibody that detects SCAND2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-SCAND2 antibody (D-19) is available as the non-conjugated form. SCAND2, or SCAN domain-containing protein 2, is a 306 amino acid nuclear protein that plays a crucial role in transcriptional regulation, influencing gene expression and cellular responses. SCAND2 features a SCAN box domain, a conserved motif approximately 60 amino acids in length that facilitates protein-protein interactions, which is essential for its function in transcriptional complexes. SCAND2 is unique among SCAN box domain-containing proteins as SCAND2 lacks a C2H2-type zinc-finger domain, which is typically involved in DNA binding. SCAND2 gene is a fusion gene formed by the retropositioning of a PHD2 (also known as EGLN1) gene copy from chromosome 1 onto an ancestral SCAN zinc finger gene, followed by exon shuffling, resulting in a protein that combines features from both parent genes. SCAND2 exists as two isoforms produced by alternative splicing, which may contribute to its functional diversity in various cellular contexts.

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SCAND2 Antibody (D-19) References:

1. The zinc finger-associated SCAN box is a conserved oligomerization domain.  |  Williams, AJ., et al. 1999. Mol Cell Biol. 19: 8526-35. PMID: 10567577
2. The SCAN domain mediates selective oligomerization.  |  Schumacher, C., et al. 2000. J Biol Chem. 275: 17173-9. PMID: 10747874
3. Mapping, characterization, and expression analysis of the SM-20 human homologue, c1orf12, and identification of a novel related gene, SCAND2.  |  Dupuy, D., et al. 2000. Genomics. 69: 348-54. PMID: 11056053
4. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.  |  Epstein, AC., et al. 2001. Cell. 107: 43-54. PMID: 11595184
5. SCAN domain-containing 2 gene (SCAND2) is a novel nuclear protein derived from the zinc finger family by exon shuffling.  |  Dupuy, D., et al. 2002. Gene. 289: 1-6. PMID: 12036577

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SCAND2 Antibody (D-19) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-SCAND2 Antibody (D-19) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SCAND2 Antibody (D-19) Specifications

Alternate Product Name: SCAND2

Product Clone Name: D-19

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-63

Epitope Target: SCAND2

Epitope Species: human

Product Reactivity/Detection: SCAND2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 50 µg IgG_2a kappa light chain in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for SCAND2 Antibody (D-19): N/A