SBDS Antibody (D-9): sc-271350

SBDS Antibody (D-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects SBDS protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). SBDS (D-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Shwachman-Bodian-Diamond syndrome (SBDS) protein, consisting of 249 amino acids, is a member of the UPF0023 family and plays a crucial role in RNA metabolism, which is essential for proper cellular function and gene expression. SBDS protein is predominantly located in the cytoplasm, where SBDS participates in ribosome biogenesis and the regulation of mRNA decay, highlighting its importance in maintaining cellular homeostasis. Notably, mutations in the SBDS gene lead to Shwachman-Diamond syndrome, an autosomal recessive disorder characterized by hematologic dysfunction, skeletal abnormalities, and pancreatic exocrine insufficiency, as well as an increased risk of leukemia and myelodysplasia in affected individuals. The structural features of SBDS, including its C-terminal domain with a ferredoxin-like fold and RNA-binding capabilities, along with its central three-helical bundle and N-terminal domain, are critical for its function and interaction with other proteins involved in RNA processing.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

SBDS Antibody (D-9) References:

1. Structural and mutational analysis of the SBDS protein family. Insight into the leukemia-associated Shwachman-Diamond Syndrome.  |  Shammas, C., et al. 2005. J Biol Chem. 280: 19221-9. PMID: 15701631
2. The Shwachman-Bodian-Diamond syndrome protein family is involved in RNA metabolism.  |  Savchenko, A., et al. 2005. J Biol Chem. 280: 19213-20. PMID: 15701634
3. Hematologic abnormalities in Shwachman Diamond syndrome: lack of genotype-phenotype relationship.  |  Kuijpers, TW., et al. 2005. Blood. 106: 356-61. PMID: 15769891
4. Identification of novel mutations in patients with Shwachman-Diamond syndrome.  |  Nicolis, E., et al. 2005. Hum Mutat. 25: 410. PMID: 15776428
5. The Shwachman-Diamond SBDS protein localizes to the nucleolus.  |  Austin, KM., et al. 2005. Blood. 106: 1253-8. PMID: 15860664
6. Genetic analysis of Shwachman-Diamond syndrome: phenotypic heterogeneity in patients carrying identical SBDS mutations.  |  Kawakami, T., et al. 2005. Tohoku J Exp Med. 206: 253-9. PMID: 15942154
7. Mutation analysis of SBDS in pediatric acute myeloblastic leukemia.  |  Majeed, F., et al. 2005. Pediatr Blood Cancer. 45: 920-4. PMID: 16007594
8. Shwachman-Diamond syndrome.  |  Dror, Y. 2005. Pediatr Blood Cancer. 45: 892-901. PMID: 16047374
9. Identification of a novel AluSx-mediated deletion of exon 3 in the SBDS gene in a patient with Shwachman-Diamond syndrome.  |  Costa, E., et al. 2007. Blood Cells Mol Dis. 39: 96-101. PMID: 17376717

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SBDS Antibody (D-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-SBDS Antibody (D-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SBDS Antibody (D-9) Specifications

Alternate Product Name: SBDS

Product Clone Name: D-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-250

Epitope Target: SBDS

Epitope Species: human

Product Reactivity/Detection: SBDS

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for SBDS Antibody (D-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin