Molecular structure of Sarcosine, CAS Number: 107-97-1
Sarcosine (CAS 107-97-1)
Alternate Names:
N-methylglycine; Sarcosinic acid
Application:
Sarcosine is a compound that potentiates the action of glycine on the NMDA glycine binding site
CAS Number:
107-97-1
Molecular Weight:
89.09
Molecular Formula:
C3H7NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Sarcosine′s role as an endogenous inhibitor of the Glycine Transporter 1 (GlyT1) positions it as a compound of interest within neurochemical research, particularly in studies related to neurotransmitter regulation and synaptic transmission. GlyT1 is a protein in the central nervous system, tasked with the reuptake of glycine from the synaptic cleft back into the presynaptic neuron and surrounding glial cells. This transporter plays a key role in controlling the levels of glycine, a significant modulatory neurotransmitter in the central nervous system, and a co-agonist of N-methyl-D-aspartate (NMDA) receptors.
Sarcosine (CAS 107-97-1) References
- Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. | Sreekumar, A., et al. 2009. Nature. 457: 910-4. PMID: 19212411
- D-cycloserine, sarcosine and D-serine diminish the expression of cocaine-induced conditioned place preference. | Yang, FY., et al. 2013. J Psychopharmacol. 27: 550-8. PMID: 21106609
- Is sarcosine a biomarker for prostate cancer? | Issaq, HJ. and Veenstra, TD. 2011. J Sep Sci. 34: 3619-21. PMID: 22009695
- A reflectometric interferometric nanosensor for sarcosine. | Diltemiz, SE. and Uslu, O. 2015. Biotechnol Prog. 31: 55-61. PMID: 25079110
- High-Performance Liquid Chromatographic Analysis of Sarcosine as a Fluorescent Levofloxacin Derivative. | Chung, TC., et al. 2015. J Chromatogr Sci. 53: 1310-5. PMID: 25688037
- Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. | Lee, MY., et al. 2017. J Biomed Sci. 24: 18. PMID: 28245819
- Platinum-loaded mesoporous nickel phosphonate and its electrochemical application for sarcosine detection. | Wang, Q., et al. 2019. Anal Chim Acta. 1046: 93-98. PMID: 30482306
- Amperometric sarcosine biosensor with strong anti-interference capabilities based on mesoporous organic-inorganic hybrid materials. | Wang, Q., et al. 2019. Biosens Bioelectron. 141: 111431. PMID: 31212197
- Efficacy and cognitive effect of sarcosine (N-methylglycine) in patients with schizophrenia: A systematic review and meta-analysis of double-blind randomised controlled trials. | Chang, CH., et al. 2020. J Psychopharmacol. 34: 495-505. PMID: 32122256
- Sarcosine as an add-on treatment to antipsychotic medication for people with schizophrenia: a systematic review and meta-analysis of randomized controlled trials. | Marchi, M., et al. 2021. Expert Opin Drug Metab Toxicol. 17: 483-493. PMID: 33538213
- Graphenoxide Cross-Linker Based Potentiometric Biosensor Design for Sarcosine Determination. | Ünlüer, ÖB., et al. 2021. Protein Pept Lett. 28: 1303-1311. PMID: 34629039
- Using bimetallic Au/Cu nanoplatelets for construction of facile and label-free inner filter effect-based photoluminescence sensing platform for sarcosine detection. | Lin, X., et al. 2022. Anal Chim Acta. 1192: 339331. PMID: 35057923
- Sarcosine (glycine transporter inhibitor) attenuates behavioural and biochemical changes induced by ketamine, in the rat model of schizophrenia. | Kumar, A., et al. 2023. Exp Brain Res. 241: 451-467. PMID: 36577922
- New autonomous and self-signaling biosensing device for sarcosine detection. | Hora, CS., et al. 2023. Talanta. 257: 124340. PMID: 36809692
Inhibitor of:
GlyT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sarcosine, 25 g | sc-204262 | 25 g | $45.00 | |||
Sarcosine, 100 g | sc-204262A | 100 g | $106.00 | |||
Sarcosine, 250 g | sc-204262B | 250 g | $150.00 | |||
Sarcosine, 1 kg | sc-204262C | 1 kg | $565.00 | |||
Sarcosine, 2.5 kg | sc-204262D | 2.5 kg | $819.00 | |||
Sarcosine, 5 kg | sc-204262E | 5 kg | $1450.00 |