Date published: 2026-4-24

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Sancycline (CAS 808-26-4)

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Alternate Names:
6-Demethyl-6-deoxytetracycline; Bonomycin; Norcycline
Application:
Sancycline is a rare semi-synthetic tetracycline
CAS Number:
808-26-4
Purity:
≥98%
Molecular Weight:
414.41
Molecular Formula:
C21H22N2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Sancycline is a tetracycline antibiotic that functions by inhibiting protein synthesis in bacteria. It achieves this by binding to the 30S ribosomal subunit, preventing the attachment of aminoacyl-tRNA to the mRNA-ribosome complex. This interference ultimately disrupts the elongation of the polypeptide chain during protein synthesis, leading to the inhibition of bacterial growth. Sancycline′s mechanism of action involves the disruption of the translation process, targeting the bacterial ribosome to impede the production of proteins. This mechanism effectively hinders the ability of bacteria to proliferate and cause infection, making it useful for studying bacterial protein synthesis and developing a deeper understanding of antibiotic resistance mechanisms.


Sancycline (CAS 808-26-4) References

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  10. Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.  |  Abrams, RPM., et al. 2020. Proc Natl Acad Sci U S A. 117: 31365-31375. PMID: 33229545
  11. Comparative study of doxycycline, sancycline, and 4-dedimethylamino sancycline (CMT-3) on epidermal melanogenesis.  |  Goenka, S. and Simon, SR. 2023. Arch Dermatol Res. 315: 249-257. PMID: 34751807
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Sancycline, 1 mg

sc-391700
1 mg
$96.00