Molecular structure of S 14506, CAS Number: 135721-98-1
S 14506 (CAS 135721-98-1)
Alternate Names:
4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl]ethyl]benzamide hydrochloride
Application:
S 14506 is a full, highly potent and selective SR-1A agonist
CAS Number:
135721-98-1
Purity:
99%
Molecular Weight:
443.94
Molecular Formula:
C24H26FN3O2•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
S 14506 is a full, highly potent and selective SR-1A agonist. It affects the activation mechanism by binding between the G protein interaction switch site and agonist site, possibly displaying cooperativity.
S 14506 (CAS 135721-98-1) References
- In vivo estimates of efficacy at 5-HT1A receptors: effects of EEDQ on the ability of agonists to produce lower-lip retraction in rats. | Koek, W., et al. 2000. Psychopharmacology (Berl). 149: 377-87. PMID: 10867965
- S 14506: novel receptor coupling at 5-HT(1A) receptors. | Milligan, G., et al. 2001. Neuropharmacology. 40: 334-44. PMID: 11166326
- Assessment of the dependence potential of the potent high-efficacy 5-HT1A agonist S-14506 in rats. | Goudie, AJ. and Leathley, MJ. 1994. J Psychopharmacol. 8: 213-21. PMID: 22298627
- The effects of 8-OH-DPAT on neuroinflammation after sarin exposure in mice. | Garrett, TL., et al. 2013. Toxicology. 310: 22-8. PMID: 23692952
- A drug discrimination analysis of the actions of novel serotonin1A receptor ligands in the rat using the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin. | Schreiber, R., et al. 1995. J Pharmacol Exp Ther. 275: 822-31. PMID: 7473172
- Dopamine receptor antagonist properties of S 14506, 8-OH-DPAT, raclopride and clozapine in rodents. | Protais, P., et al. 1994. Eur J Pharmacol. 271: 167-77. PMID: 7698199
- The potent activity of the 5-HT1A receptor agonists, S 14506 and S 14671, in the rat forced swim test is blocked by novel 5-HT1A receptor antagonists. | Schreiber, R., et al. 1994. Eur J Pharmacol. 271: 537-41. PMID: 7705455
- (1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists. | Schreiber, R., et al. 1995. J Pharmacol Exp Ther. 273: 101-12. PMID: 7714755
- The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes. | Gozlan, H., et al. 1995. Eur J Pharmacol. 288: 173-86. PMID: 7720779
- Post-synaptic 5-HT1A receptor involvement in yawning and penile erections induced by apomorphine, physostigmine and mCPP in rats. | Protais, P., et al. 1995. Psychopharmacology (Berl). 120: 376-83. PMID: 8539317
- Role of 5-HT1A receptors in the ability of mixed 5-HT1A receptor agonist/dopamine D2 receptor antagonists to inhibit methylphenidate-induced behaviors in rats. | Kleven, M., et al. 1996. Eur J Pharmacol. 313: 25-34. PMID: 8905325
- Discriminative stimulus effects of 8-hydroxy-2-(di-n-propylamino)tetralin in pigeons and rats: species similarities and differences. | Kleven, MS. and Koek, W. 1998. J Pharmacol Exp Ther. 284: 238-49. PMID: 9435184
- Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands. | Goudie, AJ., et al. 1998. Behav Pharmacol. 9: 699-710. PMID: 9890260
Activator of:
SR-1A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S 14506, 10 mg | sc-205497 | 10 mg | $175.00 | |||
S 14506, 50 mg | sc-205497A | 50 mg | $739.00 |