Molecular structure of S-(+)-Rolipram, CAS Number: 85416-73-5
S-(+)-Rolipram (CAS 85416-73-5)
Alternate Names:
(4S)-4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2 -one
Application:
S-(+)-Rolipram is an inhibitor of cyclic AMP-specific phosphodiesterase
CAS Number:
85416-73-5
Purity:
≥98%
Molecular Weight:
275.35
Molecular Formula:
C16H21NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
S-(+)-Rolipram is a stereoisomer of the cyclic AMP-specific phosphodiesterase (PDE IV) inhibitor Rolipram (sc-3563). S-(+)-Rolipram is demonstrated to be ten times less potent at PDE IV inhibition than (R)-(−)-Rolipram (sc-201199), and was similarly described to block antigen-induced contracts of guinea pig colonic smooth muscle ten times less effectively than (R)-(−)-Rolipram. Racemic preparations of Rolipram are described to confer neuroprotection against excitotoxic insult, and to increase wakefulness in rats through increasing cAMP availability and increasing noradrenaline release through cAMP-mediated stimulation of tyrosine hydroxylase activity.
S-(+)-Rolipram (CAS 85416-73-5) References
- Rolipram reduces excitotoxic neuronal damage. | Block, F., et al. 2001. Neuroreport. 12: 1507-11. PMID: 11388438
- Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process. | Terry, R., et al. 2003. Cell Signal. 15: 955-71. PMID: 12873709
- Coexpression of human cAMP-specific phosphodiesterase activity and high affinity rolipram binding in yeast. | Torphy, TJ., et al. 1992. J Biol Chem. 267: 1798-804. PMID: 1309798
- Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation. | Chen, RW., et al. 2007. Neurosci Lett. 418: 165-9. PMID: 17398001
- Postinjury treatment with rolipram increases hemorrhage after traumatic brain injury. | Atkins, CM., et al. 2012. J Neurosci Res. 90: 1861-71. PMID: 22535545
- Identification of novel small-molecule inhibitors of Zika virus infection. | Micewicz, ED., et al. 2018. Bioorg Med Chem Lett. 28: 452-458. PMID: 29258771
- Prevention by phosphodiesterase inhibitors of antigen-induced contraction of guinea-pig colonic smooth muscle. | Grous, M. and Barnette, M. 1994. Br J Pharmacol. 111: 259-63. PMID: 7516803
- Inhibitory effects of rolipram on partially purified phosphodiesterase 4 from rat brains. | Ohsawa, F., et al. 1998. Jpn J Pharmacol. 77: 147-54. PMID: 9681571
- Rolipram, an antidepressant that increases the availability of cAMP, transiently enhances wakefulness in rats. | Lelkes, Z., et al. 1998. Pharmacol Biochem Behav. 60: 835-9. PMID: 9700966
Inhibitor of:
PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
S-(+)-Rolipram, 5 mg | sc-201200 | 5 mg | $150.00 |