Rubella Virus core antigen Antibody (3D2): sc-52200

Rubella Virus core antigen Antibody (3D2) is a mouse monoclonal IgG2a antibody that detects Rubella Virus core antigen of Rubella Virus origin by western blotting (WB). Anti-Rubella Virus core antigen antibody (3D2) is available as the non-conjugated format. Rubella Virus is responsible for causing rubella, also known as epidemic roseola, German measles, liberty measles, or three-day measles, which is primarily transmitted through respiratory droplets from person to person. The symptoms of rubella are often mild, leading to challenges in diagnosis, yet the implications can be severe, particularly in pregnant women, as congenital rubella syndrome (CRS) can result in serious birth defects in the developing fetus if the mother contracts the virus during her first trimester. Rubella Virus core antigen plays a crucial role in the virus′s life cycle, particularly in the assembly and secretion of virions. Notably, Rubella Virus core antigen undergoes post-translational modifications, including phosphorylation, which is essential for the early stages of virus replication. While the phosphorylation state does not directly affect the synthesis of viral RNA and proteins, phosphorylation remains critical for the uncoating of virions and/or disassembly of nucleocapsids, thereby facilitating viral infection of host cells.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Rubella Virus core antigen Antibody (3D2) References:

1. Evaluation of antibodies against a rubella virus neutralizing domain for determination of immune status.  |  Cordoba, P., et al. 2000. Clin Diagn Lab Immunol. 7: 964-6. PMID: 11063507
2. Structural maturation of rubella virus in the Golgi complex.  |  Risco, C., et al. 2003. Virology. 312: 261-9. PMID: 12919732
3. Evaluation of cis-acting elements in the rubella virus subgenomic RNA that play a role in its translation.  |  Pappas, CL., et al. 2006. Arch Virol. 151: 327-46. PMID: 16172842
4. Analyses of phosphorylation events in the rubella virus capsid protein: role in early replication events.  |  Law, LJ., et al. 2006. J Virol. 80: 6917-25. PMID: 16809297
5. Congenital rubella syndrome with positive serology and virus isolation.  |  Ooi, HL., et al. 2006. Med J Malaysia. 61: 248-50. PMID: 16898324
6. Specific binding of host cell proteins to the 3'-terminal stem-loop structure of rubella virus negative-strand RNA.  |  Nakhasi, HL., et al. 1991. J Virol. 65: 5961-7. PMID: 1920622
7. Chimeric derivatives of hepatitis B virus core particles carrying major epitopes of the rubella virus E1 glycoprotein.  |  Skrastina, D., et al. 2013. Clin Vaccine Immunol. 20: 1719-28. PMID: 24006140
8. Diagnosis of rubella virus using antigen-conjugated Au@Pt nanorods as nanozyme probe.  |  Zhang, T., et al. 2018. Int J Nanomedicine. 13: 4795-4805. PMID: 30197515
9. Antigen-labeled mesoporous silica-coated Au-core Pt-shell nanostructure: a novel nanoprobe for highly efficient virus diagnosis.  |  Li, A., et al. 2019. J Biol Eng. 13: 87. PMID: 31807139
10. Granulomatous inflammation in inborn errors of immunity.  |  Sacco, KA., et al. 2023. Front Pediatr. 11: 1110115. PMID: 36891233
11. Structure and function of the rubella virus proteins.  |  Dorsett, PH., et al. 1985. Rev Infect Dis. 7 Suppl 1: S150-6. PMID: 4001722
12. Assembly of rubella virus structural proteins into virus-like particles in transfected cells.  |  Hobman, TC., et al. 1994. Virology. 202: 574-85. PMID: 8030223