Molecular structure of Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt, CAS Number: 73208-40-9
Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt (CAS 73208-40-9)
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Alternate Names:
RP-CAMPS
Application:
Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt is a PKA inhibitor
CAS Number:
73208-40-9
Molecular Weight:
367.3
Molecular Formula:
C10H11N5O5PS•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt (Rp-cAMP), a membrane permeable compound, is shown to be an an inhibitor of PKA (cAMP-dependent). This compound displays a capacity to inhibit dbcAMP- and Sp-cAMPS (sc -201571)-induced stimulation of bone resorption in mice. Furthermore, due to its effects on cAMP, Rp-cAMP can also inhibit cAMP mediated cell growth of certain cells. Other effects of PKA activation inhibition noted include a decrease in glucagon-induced glycogenolysis in hepatocytes isolated from fed rats.
Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt (CAS 73208-40-9) References
- Rp-cAMPS has no effect on adenosine A1 receptors in guinea-pig cardiomyocytes. | Adamson, DL. and Harding, SE. 2000. Basic Res Cardiol. 95: 114-8. PMID: 10826503
- cAMP-dependent protein kinase and reward-related learning: intra-accumbens Rp-cAMPS blocks amphetamine-produced place conditioning in rats. | Beninger, RJ., et al. 2003. Psychopharmacology (Berl). 170: 23-32. PMID: 12768275
- The activation of cAMP-dependent protein kinase is directly linked to the stimulation of bone resorption by parathyroid hormone. | Kaji, H., et al. 1992. Biochem Biophys Res Commun. 182: 1356-61. PMID: 1311571
- Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. | Yokozaki, H., et al. 1992. Cancer Res. 52: 2504-8. PMID: 1314695
- Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. | Wang, LY., et al. 1991. Science. 253: 1132-5. PMID: 1653455
- Identifying the molecular switches that determine whether (Rp)-cAMPS functions as an antagonist or an agonist in the activation of cAMP-dependent protein kinase I. | Dostmann, WR. and Taylor, SS. 1991. Biochemistry. 30: 8710-6. PMID: 1653606
- A study of the mechanism of glucagon-induced protein phosphorylation in isolated rat hepatocytes using (Sp)-cAMPS and (Rp)-cAMPS, the stimulatory and inhibitory diastereomers of adenosine cyclic 3',5'-phosphorothioate. | Connelly, PA., et al. 1987. J Biol Chem. 262: 4324-32. PMID: 3031072
- Inhibition of glucagon-induced glycogenolysis in isolated rat hepatocytes by the Rp diastereomer of adenosine cyclic 3',5'-phosphorothioate. | Rothermel, JD., et al. 1984. J Biol Chem. 259: 8151-5. PMID: 6330102
- (RP)-cAMPS inhibits the cAMP-dependent protein kinase by blocking the cAMP-induced conformational transition. | Dostmann, WR. 1995. FEBS Lett. 375: 231-4. PMID: 7498506
- Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action. | Gjertsen, BT., et al. 1995. J Biol Chem. 270: 20599-607. PMID: 7657638
- Use of the cyclic AMP antagonist, Rp-cAMPS, to distinguish between cyclic AMP-dependent and cyclic AMP-independent contractile responses in rat ventricular cardiomyocytes. | Bell, D. and McDermott, BJ. 1994. J Mol Cell Cardiol. 26: 1439-48. PMID: 7897668
- Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. | Musgrave, IF., et al. 1993. FEBS Lett. 318: 227-30. PMID: 8382631
- Rp diastereomeric analogs of cAMP inhibit both cAMP- and cGMP-induced dilation of hamster mesenteric small arteries. | Jackson, WF. 1996. Pharmacology. 52: 226-34. PMID: 8841085
Inhibitor of:
PKA, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Rp-Adenosine 3′,5′-cyclic Monophosphorothioate, Sodium Salt, 1 mg | sc-202038 | 1 mg | $197.00 |